Abstract | BACKGROUND: METHODS: The infrarenal aortas of New Zealand White albino rabbits (n = 40) were occluded for 40 minutes. Experimental groups were as follows: sham operation group (n = 5), control group undergoing occlusion but receiving no pharmacologic intervention (n = 10), experimental group A (n = 10) receiving 8 mg/kg riluzole intravenously 30 minutes before ischemia, experimental group B (n = 10) receiving 4 mg/kg riluzole intravenously 30 minutes before ischemia and at the onset of reperfusion, and experimental group C (n = 10) receiving 8 mg/kg riluzole intravenously at the onset of reperfusion. Neurologic status was assessed at 6, 24, and 48 hours after the operation and then daily until the fifth day. All animals were killed at 24, 48, or 120 hours after the operation. Spinal cords were harvested for histopathologic studies, immunohistochemical studies for microtubule-associated protein 2, and search for morphologic features of apoptosis by the terminal deoxynucleotidyltransferase-mediated deoxyuridine triphosphate- biotin nick-end labeling staining method. RESULTS: CONCLUSION:
Riluzole may have therapeutic utility during high-risk operations on the thoracoabdominal aorta.
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Authors | L Lang-Lazdunski, C Heurteaux, N Vaillant, C Widmann, M Lazdunski |
Journal | The Journal of thoracic and cardiovascular surgery
(J Thorac Cardiovasc Surg)
Vol. 117
Issue 5
Pg. 881-9
(May 1999)
ISSN: 0022-5223 [Print] United States |
PMID | 10220679
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Microtubule-Associated Proteins
- Neuroprotective Agents
- Riluzole
- DNA
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Topics |
- Animals
- Aorta, Abdominal
(surgery)
- Apoptosis
(genetics)
- Constriction
- Cytoplasm
(metabolism)
- DNA
(analysis)
- DNA Fragmentation
- Disease Models, Animal
- Female
- Immunoenzyme Techniques
- In Situ Nick-End Labeling
- Injections, Intravenous
- Ischemia
(metabolism, pathology, prevention & control)
- Microtubule-Associated Proteins
(metabolism)
- Motor Neurons
(drug effects, metabolism, pathology)
- Necrosis
- Neuroprotective Agents
(administration & dosage, therapeutic use)
- Photomicrography
- Rabbits
- Riluzole
(administration & dosage, therapeutic use)
- Spinal Cord
(blood supply, drug effects, metabolism)
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