Cardioprotection for Duchenne's muscular dystrophy.

Abstract

PURPOSE:

To explore the use of neuroendocrine monitoring for more timely diagnosis of dilated cardiomyopathy (DCM) in Duchenne's muscular dystrophy (DMD) and to determine the effects of angiotensin-converting enzyme inhibitors (ACEI) and beta-blockers on neuroendocrine levels, left ventricular diastolic diameter (LVDd), ejection fraction, and mortality rate on DMD.

METHODS:

Eighty-five patients with DMD underwent yearly cardiac monitoring including neuroendocrine screening. Eleven patients had symptoms of DCM develop once plasma neuroendocrine levels increased. At this point the patients received ACEI for 9 to 62 months (35.8 +/- 18.4 months) and beta-blockers for 7 to 60 months (31.6 +/- 20.1 months).

RESULTS:

The combination of ACEI and beta-blockers relieved symptoms and signs of heart failure in all 11 patients and significantly reduced atrial natriuretic protein (ANP) levels from 197.5 +/- 152.1 pg/mL to 25.5 +/- 16.2 pg/mL ( P <.002) at 15.5 +/- 8.2 months, brain natriuretic protein from 523.8 +/- 434.8 pg/mL to 59.3 +/- 24. 2 pg/mL ( P <.05) at 12.2 +/- 3.1 months (data complete for 5 patients), norepinephrine levels from 1114 +/- 689 pg/mL to 360 +/- 257 pg/mL at 20.5 +/- 9.6 months for 11 patients (P =.001), and LVDd from 65.9 +/- 9.2 mm to 63.3 +/- 6.3 mm (P =.15) at 15.0 +/- 7.4 months for 10 patients, including 3 for whom the LVDd increased by 2 to 6 mm. The combination increased left ventricular ejection fraction (LVEF) from 25.1% +/- 9.2% to 36.5% +/- 5.8% (P <.001) at 17.1 +/- 11.0 months for 10 patients. For 9 of the patients ANP levels remained lower throughout the 36.8 +/- 20.1 month course of the follow-up. Two patients had sudden severe re-elevations of ANP levels just before death from congestive heart failure after 44 and 23 months of therapy, respectively.

CONCLUSION:

Neuroendocrine level monitoring can assist in the diagnosis of DCM in patients with DMD. Combination therapy with ACEI and beta-blockers can significantly decrease neuroendocrine activation and LVDd and reverse symptoms and signs of congestive heart failure for patients with DMD.

• Authors: Y Ishikawa, J R Bach, R Minami
• Journal: American heart journal (Am Heart J) Vol. 137 Issue 5 Pg. 895-902 (May 1999) ISSN: 0002-8703 [Print] United States
• PMID: 10220639 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Adrenergic beta-Antagonists
• Angiotensin-Converting Enzyme Inhibitors
• Biomarkers
• Natriuretic Peptide, Brain
• Atrial Natriuretic Factor
• Norepinephrine

Topics

• Adolescent
• Adrenergic beta-Antagonists (therapeutic use)
• Adult
• Angiotensin-Converting Enzyme Inhibitors (therapeutic use)
• Atrial Natriuretic Factor (blood)
• Biomarkers (blood)
• Child
• Follow-Up Studies
• Heart Failure (blood, etiology, prevention & control)
• Heart Ventricles (physiopathology)
• Humans
• Muscular Dystrophies (blood, complications, mortality)
• Natriuretic Peptide, Brain (blood)
• Norepinephrine (blood)
• Severity of Illness Index
• Stroke Volume
• Survival Rate