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Diabetic gustatory sweating successfully treated with topical glycopyrrolate: report of a case and review of the literature.

AbstractBACKGROUND:
Gustatory sweating is a more common manifestation of diabetes mellitus than is appreciated. It is a distressing problem that has been difficult to treat safely.
METHODS:
Daily topical application of glycopyrrolate roll-on lotion was offered as an alternative to oral anticholinergic agents to an 87-year-old woman with long-standing type 2 diabetes mellitus who complained of profuse sweating after eating.
RESULTS:
Gustatory sweating was relieved by application of glycopyrrolate and reappeared when the glycopyrrolate was briefly withdrawn to confirm its therapeutic effect.
CONCLUSION:
For moderate to severe symptoms of diabetic gustatory sweating, topical application of glycopyrrolate is safe, effective, well tolerated, and convenient.
AuthorsJ D Urman, A M Bobrove
JournalArchives of internal medicine (Arch Intern Med) Vol. 159 Issue 8 Pg. 877-8 (Apr 26 1999) ISSN: 0003-9926 [Print] United States
PMID10219935 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Muscarinic Antagonists
  • Parasympatholytics
  • Glycopyrrolate
Topics
  • Administration, Cutaneous
  • Aged
  • Aged, 80 and over
  • Diabetes Mellitus, Type 2 (complications)
  • Female
  • Glycopyrrolate (administration & dosage, therapeutic use)
  • Humans
  • Muscarinic Antagonists (administration & dosage, therapeutic use)
  • Parasympatholytics (administration & dosage, therapeutic use)
  • Sweating, Gustatory (drug therapy, etiology)

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