Abstract | PURPOSE: The aim of this study was to fully characterize newly developed radioactive rhenium glass microspheres in vivo by determining their biodistribution, stability, antitumor effect, and toxicity after hepatic arterial injection in a syngeneic rat hepatoma model. The dose response of the tumors to increasing amounts of radioactive 186Re and 188Re microspheres was also determined. METHODS AND MATERIALS:
Rhenium glass microspheres were made radioactive by neutron activation and then injected into the hepatic artery of Sprague-Dawley rats containing 1-week-old Novikoff hepatomas. The biodistribution of the radioactivity and tumor growth were determined 1 h and 14 days after injection. RESULTS: Examination of the biodistribution indicated a time-dependent, up to 7-fold increase in Novikoff hepatoma uptake as compared to healthy liver tissue uptake. After 14 days, the average T:L ratio was 1.97. Tumor growth in the rats receiving radioactive microspheres was significantly lower than in the group receiving nonradioactive microspheres (142% vs. 4824%, p = 0.048). Immediately after injection, 0.065% of the injected radioactivity was measured in the thyroid; it decreased to background levels within 24 h. CONCLUSION:
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Authors | U O Häfeli, S Casillas, D W Dietz, G J Pauer, L A Rybicki, S D Conzone, D E Day |
Journal | International journal of radiation oncology, biology, physics
(Int J Radiat Oncol Biol Phys)
Vol. 44
Issue 1
Pg. 189-99
(Apr 01 1999)
ISSN: 0360-3016 [Print] United States |
PMID | 10219814
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Radioisotopes
- Radiopharmaceuticals
- Rhenium
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Topics |
- Animals
- Drug Screening Assays, Antitumor
- Embolization, Therapeutic
(methods)
- Liver Neoplasms, Experimental
(metabolism, pathology, radiotherapy)
- Male
- Microspheres
- Radioisotopes
(pharmacokinetics, therapeutic use)
- Radiopharmaceuticals
(pharmacokinetics, therapeutic use)
- Rats
- Rats, Sprague-Dawley
- Rhenium
(pharmacokinetics, therapeutic use)
- Tissue Distribution
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