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Insulin-degrading enzyme in the Alzheimer's disease brain: prominent localization in neurons and senile plaques.

Abstract
The anatomical distribution of insulin-degrading enzyme (IDE) was studied in normal and Alzheimer's disease (AD) human brains. By use of a monospecific, polyclonal antiserum against the enzyme we identified IDE antigen in multiple cortical and subcortical neurons. Glia did not show IDE immunoreactivity. In AD brains immunostaining appeared stronger than in controls and appeared not only in neurons but also in senile plaques. In a probable case of Lewy body variant of AD Lewy bodies in neurons of the Nuc. basalis of Meynert were immunopositive for IDE. Our anatomical data suggest that the enzyme is associated with typical neuropathologic hallmarks of AD and its expression appears up-regulated in some brain areas.
AuthorsH G Bernstein, S Ansorge, P Riederer, M Reiser, L Frölich, B Bogerts
JournalNeuroscience letters (Neurosci Lett) Vol. 263 Issue 2-3 Pg. 161-4 (Mar 26 1999) ISSN: 0304-3940 [Print] Ireland
PMID10213160 (Publication Type: Journal Article)
Chemical References
  • Insulysin
Topics
  • Adult
  • Aged
  • Alzheimer Disease (enzymology, pathology)
  • Brain (enzymology, pathology)
  • Female
  • Humans
  • Insulysin (analysis, metabolism)
  • Male
  • Neurites (enzymology, pathology)
  • Neurons (enzymology, pathology)
  • Plaque, Amyloid (enzymology)
  • Pyramidal Cells (enzymology, pathology)

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