Immunohistochemical expression of the sialyl Lewis x antigen on gastric cancer cells correlates with the presence of liver metastasis.

Abstract

The expression of the sialyl Lewis x antigen (sLe(x)) on surgical specimens of primary gastric cancer correlates with the degree of differentiation and synchronous and metachronous liver metastasis. Multivariate analysis by means of Quantification theory II revealed that sLe(x) expression was an independent risk factor for liver metastasis from gastric cancer.

• Authors: M Tatsumi, A Watanabe, H Sawada, Y Yamada, Y Shino, H Nakano
• Journal: Clinical & experimental metastasis (Clin Exp Metastasis) Vol. 16 Issue 8 Pg. 743-50 (Nov 1998) ISSN: 0262-0898 [Print] Netherlands
• PMID: 10211987 (Publication Type: Journal Article)

Chemical References

• Antigens, Tumor-Associated, Carbohydrate
• Biomarkers, Tumor
• CA-19-9 Antigen
• Gangliosides
• Oligosaccharides
• Sialyl Lewis X Antigen
• sialyl Le(a) ganglioside

Topics

• Aged
• Animals
• Antigens, Tumor-Associated, Carbohydrate (biosynthesis)
• Biomarkers, Tumor (biosynthesis)
• CA-19-9 Antigen
• Female
• Gangliosides (biosynthesis)
• Gastric Mucosa (metabolism)
• Humans
• Immunohistochemistry
• Liver Neoplasms (metabolism, pathology, secondary)
• Male
• Middle Aged
• Multivariate Analysis
• Oligosaccharides (biosynthesis)
• Prognosis
• Risk Factors
• Sialyl Lewis X Antigen
• Stomach Neoplasms (metabolism, pathology)