Abstract | PURPOSE: By considering the pathophysiologic basis of inflammatory bowel diseases, a role for excessive lipid peroxidation caused by oxygen free radical compounds has been proposed repeatedly. However, to date only a few studies are available on this topic in human beings. This study was designed to assess breath alkanes in a group of patients with active inflammatory bowel disease by a technique that clearly distinguishes pentane from isoprene, to prevent overestimation of values as in previous studies. PATIENTS: METHODS: Breath alkanes determination was performed by a standard procedure involving a gas chromatography column able to separate pentane from isoprene. RESULTS: CONCLUSIONS: An excess of lipid peroxidation is probably an important pathogenetic factor in inflammatory bowel diseases, and this may be assessed through a noninvasive method. Because this method previously also has been shown to be able to evaluate disease activity, it could be a useful tool for studying patients with inflammatory bowel diseases.
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Authors | M A Pelli, G Trovarelli, E Capodicasa, G E De Medio, G Bassotti |
Journal | Diseases of the colon and rectum
(Dis Colon Rectum)
Vol. 42
Issue 1
Pg. 71-6
(Jan 1999)
ISSN: 0012-3706 [Print] United States |
PMID | 10211523
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Alkanes
- Butadienes
- Butanes
- Hemiterpenes
- Pentanes
- Reactive Oxygen Species
- isoprene
- pentane
- butane
- Ethane
- Propane
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Topics |
- Adolescent
- Adult
- Alkanes
(analysis)
- Breath Tests
- Butadienes
(analysis)
- Butanes
(analysis)
- Child
- Chromatography, Gas
- Colitis, Ulcerative
(metabolism)
- Crohn Disease
(metabolism)
- Ethane
(analysis)
- False Positive Reactions
- Female
- Hemiterpenes
- Humans
- Lipid Peroxidation
- Male
- Middle Aged
- Pentanes
(analysis)
- Propane
(analysis)
- Reactive Oxygen Species
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