Abstract | PURPOSE: METHODS: Rats were randomly divided into four groups. Rats in Group RV underwent ring attachment around the rectum to induce partial obstruction and ligation of the marginal vessels of the left colon. As control, rats in Group R underwent the ring attachment and rats in Group V underwent the vascular ligation. Rat in Group C underwent sham operation. The effects of TCV-309 on lesion formation in the colon were evaluated. Thiobarbituric acid reactant level was determined in colonic mucosa, and the incidence and severity of ischemic lesions were also determined. RESULTS: Lesions of colitis were frequently observed in Group RV. TCV-309 did not prevent lesion formation, nor did it suppress the increase in thiobarbituric acid reactant level in Group RV. However, TCV-309 mitigated the severity of the lesion. CONCLUSIONS:
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Authors | Y Nagahata, Y Azumi, T Akimoto, H Nomura, T Ichihara, H Idei, Y Kuroda |
Journal | Diseases of the colon and rectum
(Dis Colon Rectum)
Vol. 42
Issue 2
Pg. 218-24
(Feb 1999)
ISSN: 0012-3706 [Print] United States |
PMID | 10211499
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Isoquinolines
- Platelet Activating Factor
- Platelet Aggregation Inhibitors
- Pyridinium Compounds
- Tetrahydroisoquinolines
- Thiobarbiturates
- thiobarbituric acid
- TCV 309
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Topics |
- Animals
- Colitis, Ischemic
(pathology)
- Colon
(drug effects)
- Intestinal Mucosa
(drug effects)
- Isoquinolines
(pharmacology)
- Male
- Platelet Activating Factor
(physiology)
- Platelet Aggregation Inhibitors
(pharmacology)
- Pyridinium Compounds
(pharmacology)
- Random Allocation
- Rats
- Rats, Wistar
- Tetrahydroisoquinolines
- Thiobarbiturates
(pharmacology)
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