A series of novel dithiocarbamates, disodium
salts of N-glucamyl-N-dithiocarboxyl-
amino acids, were synthesized, and their usefullness as an antagonist of
cadmium intoxication was investigated. These
chelating agents were found to be effective in both acute and repeated exposure
cadmium poisoning. The results showed that the
cadmium mobilizing properties of disodium N-(2,3,4,5, 6-pentahydroxylhexyl)-N-dithiocarbamate-L-threoninate and disodium N-(2,3,4,5,6-pentahydroxylhexyl)-N-dithiocarbamate-L-cysteinate are clearly superior to those of
sodium N-(4-methoxybenzyl)-D-glucamine-N-carbodithioate (
MeOBGDTC) revealed in the experiments described here. The toxicity of these novel compounds is modest, and their effect on the concentrations of essential
metal ions in the renal cortex is quite small in comparison with that of a group treated with
cadmium only. The new dithiocarbomates were identified by MS, rather than by elemental analysis, as they were extremely hygroscopic.