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[Vascular endothelial cell dysfunction in diabetes mellitus].

Abstract
Diabetes mellitus is complicated with vascular disorders such as atherosclerosis (macroangiopathy) and retinopathy (microangiopathy). In macroangiopathy, AGE plays an important role in atherogesis through NF-kappa B activation, that induces VCAM-1 and MCP-1. Diabetic retinopathy is based on the microangiopathy characteristic of angiogenesis. VEGF is a key substance in the angiogenesis in the retina. VEGF is produced from retinal cells exposed to AGE, adenosine, bFGF. VEGF elictes angiogenesis and increased vascular permeability (retinal edema). I consider that AGE is the most important substance in diabetic vascular disorder. Therefore, I expect a new application for diabetic angiopathy to suppress the effect of AGE.
AuthorsH Fujita
JournalNihon rinsho. Japanese journal of clinical medicine (Nihon Rinsho) Vol. 57 Issue 3 Pg. 573-7 (Mar 1999) ISSN: 0047-1852 [Print] Japan
PMID10199136 (Publication Type: English Abstract, Journal Article, Review)
Topics
  • Diabetic Angiopathies (etiology)
  • Diabetic Retinopathy (etiology)
  • Endothelium, Vascular (cytology, physiology)
  • Humans

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