Abstract |
Diabetes mellitus is complicated with vascular disorders such as atherosclerosis (macroangiopathy) and retinopathy (microangiopathy). In macroangiopathy, AGE plays an important role in atherogesis through NF-kappa B activation, that induces VCAM-1 and MCP-1. Diabetic retinopathy is based on the microangiopathy characteristic of angiogenesis. VEGF is a key substance in the angiogenesis in the retina. VEGF is produced from retinal cells exposed to AGE, adenosine, bFGF. VEGF elictes angiogenesis and increased vascular permeability ( retinal edema). I consider that AGE is the most important substance in diabetic vascular disorder. Therefore, I expect a new application for diabetic angiopathy to suppress the effect of AGE.
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Authors | H Fujita |
Journal | Nihon rinsho. Japanese journal of clinical medicine
(Nihon Rinsho)
Vol. 57
Issue 3
Pg. 573-7
(Mar 1999)
ISSN: 0047-1852 [Print] Japan |
PMID | 10199136
(Publication Type: English Abstract, Journal Article, Review)
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Topics |
- Diabetic Angiopathies
(etiology)
- Diabetic Retinopathy
(etiology)
- Endothelium, Vascular
(cytology, physiology)
- Humans
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