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Sustained anabolic effects of long-term androgen administration in men with AIDS wasting.

Abstract
Fifty-one human immunodeficiency virus-positive men with hypogonadism and wasting were randomized to receive testosterone enanthate, 300 mg i.m. every 3 weeks, or placebo for 6 months, followed by open-label testosterone administration for 6 months. Subjects initially randomized to placebo gained lean body mass (LBM) only after crossover to testosterone administration (mean change +/- standard error of the mean, -0.6 +/- 0.7 kg [months 0-6] vs. 1.9 +/- 0.7 kg [months 6-12]; P = .03). In contrast, subjects initially randomized to testosterone continued to gain LBM during open-label administration (2.0 +/- 0.7 kg [months 0-6] vs. 1.6 +/- 0.6 kg [months 6-12]; P = .62) and had gained more LBM at 1 year than did subjects receiving testosterone for only the final 6 months of the study (3.7 +/- 0.8 kg vs. 1.0 +/- 1.0 kg; P = .05). Testosterone administration results in sustained increases in LBM during 1 year of therapy in hypogonadal men with AIDS wasting.
AuthorsS Grinspoon, C Corcoran, E Anderson, J Hubbard, T Stanley, N Basgoz, A Klibanski
JournalClinical infectious diseases : an official publication of the Infectious Diseases Society of America (Clin Infect Dis) Vol. 28 Issue 3 Pg. 634-6 (Mar 1999) ISSN: 1058-4838 [Print] United States
PMID10194091 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Testosterone
  • testosterone enanthate
Topics
  • Cross-Over Studies
  • HIV Wasting Syndrome (complications, drug therapy, physiopathology)
  • Humans
  • Hypogonadism (complications, drug therapy)
  • Male
  • Quality of Life
  • Testosterone (administration & dosage, adverse effects, analogs & derivatives, therapeutic use)
  • Time Factors
  • Weight Gain

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