Antiperinuclear factor and antibodies to the stratum corneum of rat esophagus in juvenile idiopathic arthritis.

Abstract

We analyzed the frequency and clinical correlates of antiperinuclear factor (APF) and antibodies to the stratum corneum of rat esophagus in 86 children with juvenile idiopathic arthritis (JIA), 32 children with juvenile systemic lupus erythematosus, and 52 healthy children. Forty-two patients with JIA (49%) were positive for APF. No association was observed between APF and current age, sex, JIA subtype, age at disease onset, or disease duration. APF was found in one patient with juvenile systemic lupus erythematosus and in no healthy child. Antibodies to the stratum corneum of rat esophagus were detected in 3 patients with polyarticular JIA. APF may be a valuable tool in the differential diagnosis of JIA.

• Authors: C R Serra, S H Rodrigues, F R Sztajnbok, N P Silva, L E Andrade
• Journal: The Journal of pediatrics (J Pediatr) Vol. 134 Issue 4 Pg. 507-9 (Apr 1999) ISSN: 0022-3476 [Print] United States
• PMID: 10190929 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies
• Antibodies, Antinuclear
• antiperinuclear factor
• Keratins
• Rheumatoid Factor

Topics

• Animals
• Antibodies (blood)
• Antibodies, Antinuclear (blood)
• Arthritis, Juvenile (blood)
• Child, Preschool
• Female
• Fluorescent Antibody Technique, Indirect
• Humans
• Keratins (immunology)
• Lupus Erythematosus, Systemic (blood)
• Male
• Rats
• Reference Values
• Rheumatoid Factor (blood)