[Effect of compression with aerosolized fibrin sealant on surgical hemostasis].

Abstract

In order to decrease complications following incomplete hemostasis after surgery, especially in the case of arterial bleeding, we experimentally investigated an effective way of applying fibrin glue as a sealant. Using white rabbits as a model, in which arterial bleeding from the abdominal aorta was induced, fibrin glue and a related hemostatic agent were tested to evaluate the hemostatic effectiveness. Group I (n = 9): Fibrin glue was applied by spraying it on the fingertip and then placing the fingertip on the bleeding part and pressing. Group II (n = 9): Fibrin glue was applied with oxycellulose on the fingertip and then placing the fingertip on the bleeding part and pressing. The results demonstrated that: 1) Although complete hemostasis could not be obtained with finger-pressing alone in 30 second, it could be obtained in 9/9 cases 100%) in Group I but in only 3/9 cases (33%) in Group II. 2) Pressure-resistant force was higher for Group I at an earlier time after hemostasis (p < 0.05). 3) Pathological study reconfirmed the predominance of Group I. We conclude from this study that ideal hemostasis can be obtained with fibrin glue applied simply by spraying it on the fingertip and then placing the fingertip on the bleeding part and pressing.

• Authors: Y Matsui, K Yasuda
• Journal: Kyobu geka. The Japanese journal of thoracic surgery (Kyobu Geka) Vol. 52 Issue 3 Pg. 211-5 (Mar 1999) ISSN: 0021-5252 [Print] Japan
• PMID: 10097548 (Publication Type: English Abstract, Journal Article)

Chemical References

• Aerosols
• Fibrin Tissue Adhesive

Topics

• Aerosols
• Animals
• Fibrin Tissue Adhesive (administration & dosage)
• Hemostasis, Surgical (methods)
• Male
• Pressure
• Rabbits