Abstract |
To understand the mechanism of erythromycin (EM) on otitis media with effusion, we examined its effects on leukocyte accumulation and expression of adhesion molecules L-selectin and Mac-1, using a rat experimental model Administration of EM inhibited leukocyte (neutrophil) accumulation in the middle ear cavity after LPS stimulation. Moreover, EM downregulated L-selectin expression and inhibited interleukin (IL)-8-induced upregulation of Mac-1 on peripheral blood neutrophils. These finding suggests that EM may improve otitis media with effusion by inhibiting neutrophil accumulation in the middle ear cavity through modulating the expression of adhesion molecules L-selectin and Mac-1 on peripheral blood neutrophils.
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Authors | F Enomoto, G Ichikawa, I Nagaoka, T Yamashita |
Journal | Acta oto-laryngologica. Supplementum
(Acta Otolaryngol Suppl)
Vol. 539
Pg. 57-60
( 1998)
ISSN: 0365-5237 [Print] Norway |
PMID | 10095863
(Publication Type: Journal Article)
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Chemical References |
- Macrophage-1 Antigen
- L-Selectin
- Erythromycin
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Topics |
- Animals
- Down-Regulation
- Ear, Middle
(chemistry)
- Erythromycin
(pharmacology, therapeutic use)
- L-Selectin
(analysis, drug effects)
- Macrophage-1 Antigen
(analysis, drug effects)
- Neutrophils
(drug effects)
- Otitis Media with Effusion
(drug therapy, pathology)
- Rats
- Up-Regulation
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