Abstract |
As a major counterregulatory hormone of insulin, glucagon plays an important role in regulating glucose homeostasis through its binding to the glucagon receptor. Recently a missense mutation in the glucagon-receptor gene (Gly40Ser) was found to be associated with type 2 diabetes in France and Sardinia, with a frequency as high as 4.6% and 8.3%, respectively. This mutation was also found to be associated with essential hypertension in the white population with a frequency of 5.4%. To investigate the role of this mutation in the pathogenesis of type 2 diabetes and essential hypertension in Taiwanese population, we screened 121 normal controls, 213 unrelated subjects with type 2 diabetes, and 107 unrelated subjects with essential hypertension by use of polymerase chain reaction/restriction fragment length polymorphism (PCR-RFLP). None of the Taiwanese subjects recruited in the study had this receptor mutation. Our results demonstrate a strong genetic heterogeneity among the ethnic group and suggest that the Gly40Ser mutation of the glucagon receptor gene plays little role, if any, in the pathogenesis of type 2 diabetes and essential hypertension in the Taiwanese population.
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Authors | C N Huang, K C Lee, H P Wu, T Y Tai, B J Lin, L M Chuang |
Journal | Pancreas
(Pancreas)
Vol. 18
Issue 2
Pg. 151-5
(Mar 1999)
ISSN: 0885-3177 [Print] United States |
PMID | 10090412
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Blood Glucose
- Receptors, Glucagon
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Topics |
- Amino Acid Substitution
(genetics)
- Blood Glucose
(genetics)
- Body Mass Index
- Diabetes Mellitus, Type 2
(genetics)
- Female
- Genetic Testing
- Humans
- Hypertension
(genetics)
- Male
- Middle Aged
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length
- Receptors, Glucagon
(genetics)
- Taiwan
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