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Screening for the Gly40Ser mutation in the glucagon receptor gene among patients with type 2 diabetes or essential hypertension in Taiwan.

Abstract
As a major counterregulatory hormone of insulin, glucagon plays an important role in regulating glucose homeostasis through its binding to the glucagon receptor. Recently a missense mutation in the glucagon-receptor gene (Gly40Ser) was found to be associated with type 2 diabetes in France and Sardinia, with a frequency as high as 4.6% and 8.3%, respectively. This mutation was also found to be associated with essential hypertension in the white population with a frequency of 5.4%. To investigate the role of this mutation in the pathogenesis of type 2 diabetes and essential hypertension in Taiwanese population, we screened 121 normal controls, 213 unrelated subjects with type 2 diabetes, and 107 unrelated subjects with essential hypertension by use of polymerase chain reaction/restriction fragment length polymorphism (PCR-RFLP). None of the Taiwanese subjects recruited in the study had this receptor mutation. Our results demonstrate a strong genetic heterogeneity among the ethnic group and suggest that the Gly40Ser mutation of the glucagon receptor gene plays little role, if any, in the pathogenesis of type 2 diabetes and essential hypertension in the Taiwanese population.
AuthorsC N Huang, K C Lee, H P Wu, T Y Tai, B J Lin, L M Chuang
JournalPancreas (Pancreas) Vol. 18 Issue 2 Pg. 151-5 (Mar 1999) ISSN: 0885-3177 [Print] United States
PMID10090412 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Blood Glucose
  • Receptors, Glucagon
Topics
  • Amino Acid Substitution (genetics)
  • Blood Glucose (genetics)
  • Body Mass Index
  • Diabetes Mellitus, Type 2 (genetics)
  • Female
  • Genetic Testing
  • Humans
  • Hypertension (genetics)
  • Male
  • Middle Aged
  • Mutation
  • Polymerase Chain Reaction
  • Polymorphism, Restriction Fragment Length
  • Receptors, Glucagon (genetics)
  • Taiwan

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