A case of advanced esophageal cancer showing a long-term complete response with chemotherapy with nedaplatin alone.

Abstract

We describe a case of advanced esophageal cancer treated successfully by chemotherapy with nedaplatin alone. A 60-year-old male with type 2 advanced esophageal cancer, which was located in the upper part of the esophagus and had invaded adjacent organs, was treated with nedaplatin 150 mg/body (100 mg/m2) given intravenously every 4 weeks from January 6, 1991. He achieved a partial response (PR) and was discharged in March 1991. Subsequently, he received nedaplatin 75 mg/body in an out-patient setting almost every month until August 1992. Toxicities were tolerable and included mild thrombocytopenia and nausea/vomiting. From serial evaluation in October 1993, the esophageal tumor was not observed. After 7 years since initial chemotherapy was administered, he still survives without the disease.

• Authors: T Satoh, K Tsushima, S Saitoh, Y Hizawa, Y Tamura, S Fukuda, Y Yamada, H Tohno, T Takasugi, Y Sakata, A Munakata
• Journal: Japanese journal of clinical oncology (Jpn J Clin Oncol) Vol. 29 Issue 2 Pg. 106-8 (Feb 1999) ISSN: 0368-2811 [Print] England
• PMID: 10089952 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antineoplastic Agents
• Organoplatinum Compounds
• nedaplatin

Topics

• Antineoplastic Agents (administration & dosage, therapeutic use)
• Carcinoma, Squamous Cell (diagnostic imaging, drug therapy, pathology)
• Disease-Free Survival
• Drug Administration Schedule
• Esophageal Neoplasms (diagnostic imaging, drug therapy, pathology)
• Esophagoscopy
• Humans
• Infusions, Intravenous
• Male
• Middle Aged
• Organoplatinum Compounds (administration & dosage, therapeutic use)
• Radiography