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Benign and malignant hepatocellular tumors: evaluation of tumoral enhancement after mangafodipir trisodium injection on MR imaging.

Abstract
The aim of this work was to study the ability of mangafodipir trisodium (Mn-DPDP)-enhanced MR imaging in differentiating malignant from benign hepatocellular tumors. Eleven patients with pathologically proved hepatocellular carcinomas, six with focal nodular hyperplasias, and one with a single hepatocellular adenoma were examined by spin-echo and gradient-echo T1-weighted sequences before, 1 h after, and 24 h after intravenous injection of Mn-DPDP (5 micromol/kg). Quantitative analysis including enhancement and lesion-to-liver contrast-to-noise ratio, and qualitative analysis including the presence of a central area and a capsule were done on pre- and post-Mn-DPDP-enhanced images. Enhancement was observed in all the tumors with significant improvement (p < 0.05) in contrast-to-noise ratio 1 h after, and 24 h after intravenous injection of Mn-DPDP. There were no significant differences in the mean enhancement and the mean contrast-to-noise ratio (CNR) between benign and malignant tumors. No enhancement was seen within internal areas observed in 7 hepatocellular carcinomas, and in 5 focal nodular hyperplasias, and within capsules which were observed in 9 hepatocellular carcinomas. In our study, Mn-DPDP increased CNR of both benign and malignant tumors but did not enable differentiation between benign and malignant tumors of hepatocellular nature.
AuthorsC M Coffin, T Diche, A Mahfouz, M Alexandre, F Caseiro-Alves, A Rahmouni, N Vasile, D Mathieu
JournalEuropean radiology (Eur Radiol) Vol. 9 Issue 3 Pg. 444-9 ( 1999) ISSN: 0938-7994 [Print] Germany
PMID10087113 (Publication Type: Clinical Trial, Clinical Trial, Phase III, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial)
Chemical References
  • Contrast Media
  • Manganese
  • Pyridoxal Phosphate
  • Edetic Acid
  • N,N'-bis(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid
Topics
  • Adenoma, Liver Cell (diagnosis)
  • Adult
  • Aged
  • Biopsy, Needle
  • Carcinoma, Hepatocellular (diagnosis)
  • Contrast Media (administration & dosage)
  • Diagnosis, Differential
  • Edetic Acid (administration & dosage, analogs & derivatives)
  • Female
  • Follow-Up Studies
  • Humans
  • Hyperplasia (diagnosis)
  • Image Enhancement (methods)
  • Injections, Intravenous
  • Liver (pathology)
  • Liver Diseases (diagnosis)
  • Liver Neoplasms (diagnosis)
  • Magnetic Resonance Imaging
  • Male
  • Manganese (administration & dosage)
  • Middle Aged
  • Pyridoxal Phosphate (administration & dosage, analogs & derivatives)
  • Retrospective Studies

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