[Veno-occlusive disease of the liver and POEMS syndrome].

Abstract

BACKGROUND:

Veno-occlusive disease of the liver is a common cause of morbidity and mortality after chemotherapy and/or radiotherapy and bone marrow transplantation. Non thrombotic hepatic venous obstruction is characteristic, but pathogenesis of this disease remains unknown.

CASE REPORT:

In june 1993, a 58-year-old man was treated by cyclophosphamide and steroid for a POEMS syndrome. In november 1996, he developed hepatalgia, edema, ascitis and jaundice. The diagnosis of hepatic veno-occlusive disease was obtained by hepatic biopsy. Refractory ascitis was treated by transjugular intrahepatic portosystemic shunt. Gradual improvement in clinical status was observed after this therapy.

CONCLUSION:

This observation offers three original types of information: there has been no prior report of an association between veno-occlusive disease and POEMS syndrome, the role of low dose cyclophosphamide in hepatic veno-occlusive disease was certain, transjugular intrahepatic portosystemic shunt is an interesting therapy with one years remission.

• Authors: E Andrès, G Kaltenbach, B Goichot, B Lioure, M Greget, J L Schlienger, M Imler
• Journal: Presse medicale (Paris, France : 1983) (Presse Med) Vol. 28 Issue 7 Pg. 334-6 (Feb 20 1999) ISSN: 0755-4982 [Print] France
• Vernacular Title: Maladie veino-occlusive du foie et syndrome POEMS.
• PMID: 10083875 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Cyclophosphamide

Topics

• Cyclophosphamide (adverse effects, therapeutic use)
• Hepatic Veno-Occlusive Disease (chemically induced, therapy)
• Humans
• Male
• Middle Aged
• POEMS Syndrome (complications, drug therapy)
• Portasystemic Shunt, Transjugular Intrahepatic