Abstract | PURPOSE: METHODS: Retrospective review of 289 radiotherapy records of consecutively treated patients from 1988 to 1993. RESULTS: Only one of 289 patients developed erythema multiforme. Milder rashes, however, occurred in 18% of exposures to AEDs including 22% of exposures to phenytoin, compared with the expected rate of 5-10%. Most of the mild drug rashes occurred before the initiation of radiotherapy, suggesting that radiation was not the cause of these reactions. CONCLUSIONS: Severe skin rashes are rare among patients with brain tumors receiving radiation therapy and AEDs. There is, however, an increased frequency of mild drug rashes among patients with brain tumors that does not appear related to radiation.
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Authors | H J Mamon, P Y Wen, A C Burns, J S Loeffler |
Journal | Epilepsia
(Epilepsia)
Vol. 40
Issue 3
Pg. 341-4
(Mar 1999)
ISSN: 0013-9580 [Print] United States |
PMID | 10080516
(Publication Type: Journal Article)
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Chemical References |
- Anticonvulsants
- Phenytoin
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Topics |
- Adolescent
- Adult
- Aged
- Anticonvulsants
(adverse effects, therapeutic use)
- Astrocytoma
(complications, radiotherapy)
- Brain Neoplasms
(complications, radiotherapy)
- Drug Eruptions
(diagnosis, epidemiology, etiology)
- Drug Therapy, Combination
- Epilepsy
(drug therapy, etiology)
- Erythema Multiforme
(chemically induced, diagnosis, epidemiology)
- Female
- Humans
- Male
- Middle Aged
- Phenytoin
(adverse effects, therapeutic use)
- Radiodermatitis
(epidemiology)
- Radiotherapy
(adverse effects)
- Retrospective Studies
- Severity of Illness Index
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