CCK(A) and 5-HT3 receptors interact in anorectic responses to amino acid deficiency.

Abstract

Serotonin3 (5-HT3) receptors in the periphery mediate anorectic responses to the amino acid deficiency, which occurs after eating amino acid-imbalanced diets (IMB). However, other neurochemical systems, notably cholecystokinin (CCK), are known to affect food intake. We pretreated rats systemically with tropisetron, a 5-HT3 receptor antagonist, alone and combined with antagonists of CCK(A) and CCK(B) receptors, and measured intake of an IMB. Devazepide, a CCK(A) receptor antagonist, appeared to interact with tropisetron in the anorectic responses to IMB, blunting the usual remediation of IMB anorexia by tropisetron. The CCK(B) receptor antagonist, L-365, 260, increased intake of both IMB and an amino acid-balanced basal diet (BAS) and did not interact with tropisetron. Our data suggest that activation of CCK(A) receptors is interactive with 5-HT3 receptor activity in mediating IMB anorexia in the aminoprivic feeding model.

• Authors: S M Aja, J A Barrett, D W Gietzen
• Journal: Pharmacology, biochemistry, and behavior (Pharmacol Biochem Behav) Vol. 62 Issue 3 Pg. 487-91 (Mar 1999) ISSN: 0091-3057 [Print] United States
• PMID: 10080241 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Amino Acids
• Benzodiazepinones
• Indoles
• Phenylurea Compounds
• Receptor, Cholecystokinin A
• Receptors, Cholecystokinin
• Receptors, Serotonin
• Receptors, Serotonin, 5-HT3
• Serotonin Antagonists
• L 365260
• Tropisetron
• Devazepide

Topics

• Amino Acids (deficiency)
• Animals
• Anorexia (physiopathology, psychology)
• Benzodiazepinones (pharmacology)
• Devazepide (pharmacology)
• Diet
• Eating (drug effects, physiology)
• Indoles (pharmacology)
• Male
• Phenylurea Compounds (pharmacology)
• Rats
• Rats, Sprague-Dawley
• Receptor, Cholecystokinin A
• Receptors, Cholecystokinin (antagonists & inhibitors, metabolism)
• Receptors, Serotonin (metabolism)
• Receptors, Serotonin, 5-HT3
• Serotonin Antagonists (pharmacology)
• Tropisetron