Abstract | BACKGROUND: METHODS: Eighteen volunteers received two bupivacaine spinal anesthetics (7.5 mg) in a randomized, double-blinded, crossover design. Dextrose, 5% (1 ml), was added to one spinal infusion and 6.25, 12.5, or 50 microg neostigmine in dextrose, 5%, was added to the other spinal. Sensory block was assessed with pinprick; by the duration of tolerance to electric stimulation equivalent to surgical incision at the pubis, knee, and ankle; and by the duration of tolerance to thigh tourniquet. Motor block at the quadriceps was assessed with surface electromyography. Side effects ( nausea, vomiting, pruritus, and sedation) were noted. Hemodynamic and respiratory parameters were recorded every 5 min. Dose-response relations were assessed with analysis of variance, paired t tests, or Spearman rank correlation. RESULTS: The addition of 50 microg neostigmine significantly increased the duration of sensory and motor block and the time until discharge criteria were achieved. The addition of neostigmine produced dose-dependent nausea (33-67%) and vomiting (17-50%). Neostigmine at these doses had no effect on hemodynamic or respiratory parameters. CONCLUSIONS:
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Authors | S S Liu, P S Hodgson, J M Moore, W J Trautman, D L Burkhead |
Journal | Anesthesiology
(Anesthesiology)
Vol. 90
Issue 3
Pg. 710-7
(Mar 1999)
ISSN: 0003-3022 [Print] United States |
PMID | 10078671
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anesthetics, Local
- Parasympathomimetics
- Neostigmine
- Glucose
- Bupivacaine
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Topics |
- Adult
- Anesthesia, Spinal
- Anesthetics, Local
(administration & dosage)
- Bupivacaine
(administration & dosage)
- Dose-Response Relationship, Drug
- Double-Blind Method
- Drug Synergism
- Female
- Glucose
(administration & dosage)
- Humans
- Male
- Neostigmine
(administration & dosage)
- Parasympathomimetics
(administration & dosage)
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