Inguinal hernia repair in patients with coagulation problems: prevention of postoperative bleeding with human fibrin glue.

Abstract

BACKGROUND:

Our purpose was to establish the efficacy of human fibrin glue (HFG) in preventing coagulative complications after inguinal hernia repair in patients with coagulation disorders.

METHODS:

A randomized controlled trial of 50 patients with coagulation disorders undergoing hernia repair was performed. Patients had concurrent coagulopathies as a consequence of liver disease or long-term treatment with anticoagulants. Coagulopathies were defined according to the following criteria: prothrombin time < 10.5 seconds, activated partial thromboplastin time < 21 seconds, and fibrinogen < 230 mg/dL. Patients were randomized in a 1:1 ratio with (group A) or without (control group B) use of HFG.

RESULTS:

Postoperative hemorrhagic complications were significantly reduced in group A (4%) compared with group B (24%).

CONCLUSION:

This study shows that HFG is effective in preventing local hemorrhagic complications after herniorrhaphy in patients with concurrent coagulation disorders. This implies that the use of HFG reduces the costs of prolonged hospitalization related to such complications.

• Authors: S Canonico, G Sciaudone, F Pacifico, A Santoriello
• Journal: Surgery (Surgery) Vol. 125 Issue 3 Pg. 315-7 (Mar 1999) ISSN: 0039-6060 [Print] United States
• PMID: 10076616 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Fibrin Tissue Adhesive

Topics

• Adult
• Aged
• Aged, 80 and over
• Blood Coagulation Disorders (complications, etiology)
• Female
• Fibrin Tissue Adhesive (therapeutic use)
• Hernia, Inguinal (complications, surgery)
• Humans
• Male
• Middle Aged
• Postoperative Hemorrhage (etiology, prevention & control)
• Prospective Studies
• Treatment Outcome