Abstract |
In this pilot study we treated cerebral vasospasm in patients with subarachnoid haemorrhage to assess intra-arterial fasudil hydrochloride. We analysed effects of intra-arterial infusion on angiographically evident cerebral vasospasm in 10 patients including 3 with symptoms of vasospasm. Over 10 to 30 min 15 to 60 mg was administered via the proximal internal carotid artery or vertebral artery following standard angiography, without superselective techniques. A total of 24 arterial territories (21 internal carotid, 3 vertebral) were treated. Angiographic improvement of vasospasm was demonstrated in 16 arterial territories (local dilation in 2, diffuse dilation in 14) in 9 patients. In 2 symptomatic patients, intra-arterial fasudil hydrochloride was associated with resolution of symptoms without sequelae. In the third symptomatic patient the benefit of fasudil hydrochloride was only temporary, and a large cerebral infarction occurred. All asymptomatic patients showed no progression of angiographic to symptomatic vasospasm after treatment with intra-arterial fasudil hydrochloride. No adverse effect was encountered.
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Authors | E Tachibana, T Harada, M Shibuya, K Saito, M Takayasu, Y Suzuki, J Yoshida |
Journal | Acta neurochirurgica
(Acta Neurochir (Wien))
Vol. 141
Issue 1
Pg. 13-9
( 1999)
ISSN: 0001-6268 [Print] Austria |
PMID | 10071681
(Publication Type: Case Reports, Clinical Trial, Journal Article)
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Chemical References |
- Vasodilator Agents
- 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
- fasudil
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Topics |
- 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
(analogs & derivatives, therapeutic use)
- Adult
- Aged
- Aneurysm, Ruptured
(complications)
- Female
- Humans
- Infusions, Intra-Arterial
- Intracranial Aneurysm
(complications)
- Ischemic Attack, Transient
(drug therapy, etiology)
- Male
- Middle Aged
- Pilot Projects
- Subarachnoid Hemorrhage
(etiology)
- Treatment Outcome
- Vasodilator Agents
(therapeutic use)
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