HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Intra-arterial infusion of fasudil hydrochloride for treating vasospasm following subarachnoid haemorrhage.

Abstract
In this pilot study we treated cerebral vasospasm in patients with subarachnoid haemorrhage to assess intra-arterial fasudil hydrochloride. We analysed effects of intra-arterial infusion on angiographically evident cerebral vasospasm in 10 patients including 3 with symptoms of vasospasm. Over 10 to 30 min 15 to 60 mg was administered via the proximal internal carotid artery or vertebral artery following standard angiography, without superselective techniques. A total of 24 arterial territories (21 internal carotid, 3 vertebral) were treated. Angiographic improvement of vasospasm was demonstrated in 16 arterial territories (local dilation in 2, diffuse dilation in 14) in 9 patients. In 2 symptomatic patients, intra-arterial fasudil hydrochloride was associated with resolution of symptoms without sequelae. In the third symptomatic patient the benefit of fasudil hydrochloride was only temporary, and a large cerebral infarction occurred. All asymptomatic patients showed no progression of angiographic to symptomatic vasospasm after treatment with intra-arterial fasudil hydrochloride. No adverse effect was encountered.
AuthorsE Tachibana, T Harada, M Shibuya, K Saito, M Takayasu, Y Suzuki, J Yoshida
JournalActa neurochirurgica (Acta Neurochir (Wien)) Vol. 141 Issue 1 Pg. 13-9 ( 1999) ISSN: 0001-6268 [Print] Austria
PMID10071681 (Publication Type: Case Reports, Clinical Trial, Journal Article)
Chemical References
  • Vasodilator Agents
  • 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
  • fasudil
Topics
  • 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine (analogs & derivatives, therapeutic use)
  • Adult
  • Aged
  • Aneurysm, Ruptured (complications)
  • Female
  • Humans
  • Infusions, Intra-Arterial
  • Intracranial Aneurysm (complications)
  • Ischemic Attack, Transient (drug therapy, etiology)
  • Male
  • Middle Aged
  • Pilot Projects
  • Subarachnoid Hemorrhage (etiology)
  • Treatment Outcome
  • Vasodilator Agents (therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: