[A case of pleural and mediastinal lymph node metastases from breast cancer effectively treated with fadrozole hydrochloride in combination with cyclophosphamide].

Abstract

A 63-year-old woman was diagnosed with pleural and mediastinal lymph node metastases 116 months after operation because of bilateral breast cancer. She was then treated with fadrozole hydrochloride (FH) (2 mg). Adriamycin (30 mg) administration into the pleural cavity was attempted, but did not prove effective. Thus, we tried to combine FH with cyclophosphamide (100 mg). After one month, chemoendocrine therapy relieved her complaints of cough and shortness of breath. CT revealed a remarkable decrease of pleural effusion and disappearance of mediastinal lymph nodes. She was alive 9 months after the treatment. Fadrozole hydrochloride in combination with cyclophosphamide is promising as an effective treatment in postmenopausal patients.

• Authors: I Kokufu, Y H Kim, Y F Peng, K Fukuda, M Yamamoto, T Yano, K Yamada, H Kitano
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 26 Issue 3 Pg. 377-9 (Feb 1999) ISSN: 0385-0684 [Print] Japan
• PMID: 10065105 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Enzyme Inhibitors
• Cyclophosphamide
• Fadrozole

Topics

• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Breast Neoplasms (drug therapy, pathology)
• Carcinoma, Ductal, Breast (drug therapy, secondary)
• Cyclophosphamide (administration & dosage)
• Enzyme Inhibitors (administration & dosage)
• Fadrozole (administration & dosage)
• Female
• Humans
• Lymph Nodes (pathology)
• Lymphatic Metastasis
• Mediastinum
• Middle Aged
• Pleura
• Pleural Effusion, Malignant (drug therapy)