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Effectiveness of 1,25-dihydroxyvitamin D supplementation on blood pressure reduction in a pseudohypoparathyroidism patient with high renin activity.

Abstract
A 42-year-old man had biochemical and somatic abnormalities compatible with pseudohypoparathyroidism type I (PsHP) and also had high plasma renin activity (PRA). After 1,25-dihydroxyvitamin D (calcitriol) supplementation the systolic/diastolic blood pressure, assessed by 24-hour non-invasive ambulatory blood pressure monitoring, was reduced from 145/96 mm Hg to 128/85 mm Hg with normalization of the serum calcium level and its related hormones, as well as decreased PRA. Calcitriol supplementation successfully reduced the blood pressure in this patient with PsHP and a high PRA, suggesting that calcium-related hormones and/or the renin-angiotensin system were involved in lowering the blood pressure.
AuthorsY Kimura, M Kawamura, M Owada, T Oshima, M Murooka, T Fujiwara, K Hiramori
JournalInternal medicine (Tokyo, Japan) (Intern Med) Vol. 38 Issue 1 Pg. 31-5 (Jan 1999) ISSN: 0918-2918 [Print] Japan
PMID10052739 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Vitamin D
  • 1,25-dihydroxyvitamin D
  • Renin
  • Calcium
Topics
  • Adult
  • Blood Pressure (drug effects)
  • Blood Pressure Monitoring, Ambulatory
  • Calcium (blood)
  • Dietary Supplements
  • Follow-Up Studies
  • Humans
  • Male
  • Pseudohypoparathyroidism (blood, diet therapy, physiopathology)
  • Renin (blood)
  • Vitamin D (analogs & derivatives, therapeutic use)

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