Abstract |
A 42-year-old man had biochemical and somatic abnormalities compatible with pseudohypoparathyroidism type I (PsHP) and also had high plasma renin activity (PRA). After 1,25-dihydroxyvitamin D ( calcitriol) supplementation the systolic/diastolic blood pressure, assessed by 24-hour non-invasive ambulatory blood pressure monitoring, was reduced from 145/96 mm Hg to 128/85 mm Hg with normalization of the serum calcium level and its related hormones, as well as decreased PRA. Calcitriol supplementation successfully reduced the blood pressure in this patient with PsHP and a high PRA, suggesting that calcium-related hormones and/or the renin-angiotensin system were involved in lowering the blood pressure.
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Authors | Y Kimura, M Kawamura, M Owada, T Oshima, M Murooka, T Fujiwara, K Hiramori |
Journal | Internal medicine (Tokyo, Japan)
(Intern Med)
Vol. 38
Issue 1
Pg. 31-5
(Jan 1999)
ISSN: 0918-2918 [Print] Japan |
PMID | 10052739
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Vitamin D
- 1,25-dihydroxyvitamin D
- Renin
- Calcium
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Topics |
- Adult
- Blood Pressure
(drug effects)
- Blood Pressure Monitoring, Ambulatory
- Calcium
(blood)
- Dietary Supplements
- Follow-Up Studies
- Humans
- Male
- Pseudohypoparathyroidism
(blood, diet therapy, physiopathology)
- Renin
(blood)
- Vitamin D
(analogs & derivatives, therapeutic use)
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