Rapid autologous marrow recovery and eradication of infectious mononucleosis despite severe immunosuppression following second transplantation for aplastic anemia.

Abstract

A patient with aplastic anemia failed to respond to immunosuppressive therapy and first marrow transplantation (BMT). Recovery of autologous hematopoiesis was rapid following a second stem cell transplant with a non-myeloablative preparatory regimen. The autologous immune response to infectious mononucleosis (IM) 4 weeks post-transplant was normal despite recent and ongoing severe immunosuppression.

• Authors: H C Rossbach, K M Hosler, W Chamizo, T Mueller, N H Grana, A G Lacson, J L Barbosa
• Journal: Bone marrow transplantation (Bone Marrow Transplant) Vol. 23 Issue 1 Pg. 91-3 (Jan 1999) ISSN: 0268-3369 [Print] England
• PMID: 10037057 (Publication Type: Case Reports, Journal Article)

Topics

• Anemia, Aplastic (therapy)
• Bone Marrow Transplantation
• Child
• Hematopoietic Stem Cell Transplantation
• Herpesvirus 4, Human (isolation & purification)
• Humans
• Immunity, Innate
• Immunosuppression Therapy
• Infectious Mononucleosis (etiology, immunology)
• Male
• Transplantation, Autologous