Abstract | PURPOSE: METHOD: Case report. RESULTS: A 52-year-old man with glioblastoma multiforme underwent left intracarotid administration of eto poside phosphate and carboplatin inferior to the ophthalmic artery. Within 7 hours, a nonpupillary block angle-closure glaucoma developed secondary to uveal effusion in the ipsilateral eye, which was relieved by cycloplegia. Four days later, severe orbital inflammation resulted in a visual acuity of counting fingers, proptosis, optic neuropathy, and total external ophthalmoplegia in the eye. The patient's condition improved after a lateral cantholysis and administration of high-dose intravenous corticosteroids. Two weeks later, an anterior uveitis occurred in the left eye, which responded to topical corticosteroids. During a 2-month period, the patient recovered to a visual acuity of 20/70, near normal motility, and normal intraocular pressure, and the ocular and orbital inflammation resolved. Preexisting ipsilateral chemotherapy-induced maculopathy became more pronounced. CONCLUSION:
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Authors | A K Lauer, J L Wobig, W T Shults, E A Neuwelt, M W Wilson |
Journal | American journal of ophthalmology
(Am J Ophthalmol)
Vol. 127
Issue 2
Pg. 230-3
(Feb 1999)
ISSN: 0002-9394 [Print] United States |
PMID | 10030580
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Organophosphorus Compounds
- etoposide phosphate
- Etoposide
- Carboplatin
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Topics |
- Antineoplastic Combined Chemotherapy Protocols
(administration & dosage, adverse effects)
- Brain Neoplasms
(drug therapy)
- Carboplatin
(administration & dosage, adverse effects)
- Carotid Artery, Internal
- Etoposide
(administration & dosage, adverse effects, analogs & derivatives)
- Eye Diseases
(chemically induced, diagnostic imaging, pathology)
- Glioblastoma
(drug therapy)
- Humans
- Infusions, Intra-Arterial
- Male
- Middle Aged
- Orbital Diseases
(chemically induced, diagnostic imaging, pathology)
- Organophosphorus Compounds
(administration & dosage, adverse effects)
- Tomography, X-Ray Computed
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