Abstract | BACKGROUND: CASE DESCRIPTION: An 18-year-old woman was admitted with akinetic mutism, which had developed 6 days after posterior fossa surgery. She had had no neurologic deficit in the first 5 days after surgery and could communicate with her family. Despite antioedematous therapy and daily lumbar punctures to drain cerebrospinal fluid, there was no clinical improvement after she entered the akinetic mute state. Brain magnetic resonance revealed ventriculomegaly; brain single photon emission computed tomography revealed bilateral reduction of perfusion in the frontal region. Because daily lumbar drainage did not result in clinical improvement, shunt placement was not considered. Bromocriptine therapy was begun at a dose of 2x2.5 mg; 24 hours later, the patient started to speak and move her upper extremities. Further improvement occurred over the following week when the dose was increased to 3x2.5 mg. Bromocriptine was replaced with a placebo to determine whether the neurologic improvement was caused by the medicine. The patient's neurologic status deteriorated progressively; therefore, bromocriptine was restarted and she was discharged from the hospital. During the 6 months of follow-up, the patient has remained in good health. CONCLUSIONS: The etiology of akinetic mutism is not clear. Monoaminergic pathways, particularly dopaminergic cell groups, are most probably involved in this syndrome, because bromocriptine has a dramatic effect on these patients, as demonstrated in our case.
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Authors | H Caner, N Altinörs, S Benli, T Calişaneller, A Albayrak |
Journal | Surgical neurology
(Surg Neurol)
Vol. 51
Issue 2
Pg. 181-4
(Feb 1999)
ISSN: 0090-3019 [Print] United States |
PMID | 10029425
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Dopamine Agonists
- Bromocriptine
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Topics |
- Adolescent
- Bromocriptine
(therapeutic use)
- Cerebral Ventricle Neoplasms
(surgery)
- Choroid Plexus
- Dopamine Agonists
(therapeutic use)
- Female
- Humans
- Movement Disorders
(drug therapy, etiology)
- Mutism
(drug therapy, etiology)
- Neurosurgical Procedures
(adverse effects)
- Papilloma
(surgery)
- Postoperative Complications
(drug therapy, etiology)
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