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No pathogenic mutations in the persyn gene in Parkinson's disease.

Abstract
The persyn (gamma-synuclein) gene is highly homologous to the alpha-synuclein gene and is highly expressed in the nervous system. It is therefore, an excellent candidate gene for Parkinson's disease. However, we have sequenced the gene in a large number of families with parkinsonism and failed to find pathogenic mutations.
AuthorsS Lincoln, K Gwinn-Hardy, J Goudreau, M C Chartier-Harlin, M Baker, V Mouroux, F Richard, A Destée, E Becquet, P Amouyel, T Lynch, J Hardy, M Farrer
JournalNeuroscience letters (Neurosci Lett) Vol. 259 Issue 1 Pg. 65-6 (Jan 04 1999) ISSN: 0304-3940 [Print] Ireland
PMID10027558 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Neoplasm Proteins
  • Nerve Tissue Proteins
  • SNCG protein, human
  • gamma-Synuclein
Topics
  • Age of Onset
  • Aged
  • Humans
  • Middle Aged
  • Mutation (genetics)
  • Neoplasm Proteins
  • Nerve Tissue Proteins (genetics)
  • Parkinson Disease (etiology, genetics)
  • Sequence Analysis, DNA (methods)
  • gamma-Synuclein

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