Proton-Coupled Folate Transporter

A symporter protein that couples the transport of FOLIC ACID with HYDROGEN IONS. The transporter functions most effectively under acidic conditions.

Also Known As:

Folate Transporter, Proton-Coupled; Solute Carrier Family 46, Member 1; Folate Transporter, Proton Coupled; Proton Coupled Folate Transporter; Transporter, Proton-Coupled Folate

Networked: 73 relevant articles (0 outcomes, 5 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Membrane Transport Proteins: 589
      - Ion Pumps: 61
        Symporters: 1442
        Proton-Coupled Folate Transporter: 73
        human SLC46A1 protein
        mouse Slc46a1 protein
        rat Slc46a1 protein
        Anion Transport Proteins: 2
        Organic Anion Transporters: 371
        Folic Acid Transporters: 21
        Proton-Coupled Folate Transporter: 73
        human SLC46A1 protein
        mouse Slc46a1 protein
        rat Slc46a1 protein
      - Solute Carrier Proteins: 34
        Proton-Coupled Folate Transporter: 73
        human SLC46A1 protein
        mouse Slc46a1 protein
        rat Slc46a1 protein
  - Membrane Proteins: 10078
    - Membrane Transport Proteins: 589
      - Ion Pumps: 61
        Symporters: 1442
        Proton-Coupled Folate Transporter: 73
        human SLC46A1 protein
        mouse Slc46a1 protein
        rat Slc46a1 protein
        Anion Transport Proteins: 2
        Organic Anion Transporters: 371
        Folic Acid Transporters: 21
        Proton-Coupled Folate Transporter: 73
        human SLC46A1 protein
        mouse Slc46a1 protein
        rat Slc46a1 protein
      - Solute Carrier Proteins: 34
        Proton-Coupled Folate Transporter: 73
        human SLC46A1 protein
        mouse Slc46a1 protein
        rat Slc46a1 protein

Experts

1.	Matherly, Larry H: 22 articles (01/2021 - 01/2009)
2.	Goldman, I David: 19 articles (01/2021 - 09/2008)
3.	Hou, Zhanjun: 19 articles (01/2021 - 10/2010)
4.	Gangjee, Aleem: 17 articles (01/2021 - 10/2010)
5.	Zhao, Rongbao: 17 articles (11/2020 - 09/2008)
6.	Kushner, Juiwanna: 10 articles (10/2018 - 10/2011)
7.	Polin, Lisa: 10 articles (10/2018 - 10/2011)
8.	White, Kathryn: 10 articles (10/2018 - 10/2011)
9.	O'Connor, Carrie: 7 articles (01/2021 - 09/2015)
10.	Wilson, Mike R: 7 articles (10/2018 - 09/2014)

Related Diseases

1.	Mesothelioma 01/01/2018 - "Proton-coupled folate transporter as a biomarker of outcome to treatment for pleural mesothelioma." 11/01/2017 - "Role of proton-coupled folate transporter in pemetrexed resistance of mesothelioma: clinical evidence and new pharmacological tools." 01/01/2020 - "Expression of proton-coupled folate transporter (PCFT) is associated with survival of mesothelioma patients treated with pemetrexed, and is reduced by hypoxia, prompting studies to elucidate their correlation. " 01/01/2020 - "Impact of hypoxia on chemoresistance of mesothelioma mediated by the proton-coupled folate transporter, and preclinical activity of new anti-LDH-A compounds." 11/01/2017 - "Here, we explored the role of the reduced-folate carrier (RFC/SLC19A1) and proton-coupled folate transporter (PCFT/SLC46A1) in antifolate resistance in mesothelioma. "
2.	Glioma (Gliomas) 01/01/2019 - "In this study, we identified the proton-coupled folate transporter (PCFT) as a route for targeted delivery of drugs to some gliomas. " 01/01/2014 - "We investigated the expression of proton-coupled folate transporter SLC46A1 in glioma and aimed to clarify the relationship between tumor fluorescence and SLC46A1 expression.We" 01/01/2019 - "Targeted Delivery of Nanoparticulate Cytochrome C into Glioma Cells Through the Proton-Coupled Folate Transporter." 01/01/2014 - "Selective accumulation of hematoporphyrin derivative in glioma through proton-coupled folate transporter SLC46A1."
3.	Temporal Lobe Epilepsy 01/01/2018 - "The aim of the current work was to study the effect of chronic temporal lobe epilepsy (TLE) on the plasma and brain concentrations of folate and on its uptake carriers in the brain - the reduced folate carrier (RFC), folate receptor α (FRα) and proton coupled folate transporter (PCFT). "
4.	Hypoxia (Hypoxemia) 01/01/2020 - "Expression of proton-coupled folate transporter (PCFT) is associated with survival of mesothelioma patients treated with pemetrexed, and is reduced by hypoxia, prompting studies to elucidate their correlation. " 01/01/2020 - "Impact of hypoxia on chemoresistance of mesothelioma mediated by the proton-coupled folate transporter, and preclinical activity of new anti-LDH-A compounds."
5.	Squamous Cell Carcinoma of Head and Neck 05/01/2019 - "The purpose of this study was to assess the expression of the 3 major folate transporters-folate receptors (FRs), reduced folate carrier (RFC), and proton-coupled folate transporter (PCFT)-in oral squamous cell carcinoma (OSCC). "

Related Drugs and Biologics

1.	Folic Acid (Vitamin M)
2.	Reduced Folate Carrier Protein
3.	Pemetrexed (MTA)
4.	Folic Acid Transporters
5.	Folic Acid Antagonists
6.	pyrimidine
7.	Proteins (Proteins, Gene)
8.	Symporters
9.	Protons (Proton)
10.	purine

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)