Reduced Folate Carrier Protein

A ubiquitously expressed folic acid transporter that functions via an antiporter mechanism which is coupled to the transport of organic phosphates.

Also Known As:

Folate Transporter 1; Reduced Folate Carrier; SLC19a1 Protein; SLC19a1 Transporter; Solute Carrier Family 19, Member 1; Carrier, Reduced Folate; Folate Carrier, Reduced; Protein, SLC19a1; Transporter 1, Folate; Transporter, SLC19a1

Networked: 217 relevant articles (5 outcomes, 37 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Matherly, Larry H: 13 articles (01/2021 - 02/2004)
2.	Assaraf, Yehuda G: 10 articles (01/2008 - 08/2002)
3.	Hou, Zhanjun: 9 articles (01/2021 - 03/2007)
4.	Gangjee, Aleem: 8 articles (01/2021 - 02/2010)
5.	Finnell, Richard H: 7 articles (08/2009 - 02/2002)
6.	Goldman, I David: 7 articles (03/2007 - 11/2002)
7.	Li, Zhu: 7 articles (05/2006 - 03/2004)
8.	Matherly, L H: 6 articles (11/2017 - 01/2001)
9.	Zhu, Huiping: 6 articles (01/2015 - 02/2002)
10.	Gorlick, Richard: 6 articles (01/2011 - 02/2003)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2021 - "Tumor-specific reliance on cytosolic 1C flux is associated with poor capacity to retain intracellular folates, which is determined by the expression of SLC19A1, which encodes the reduced folate carrier (RFC). " 12/01/2019 - "Compound 7 showed ~3-fold increased inhibition of FRα-expressing cells over its non-restricted parent analog 1 and was selectively internalized by FRα over the reduced folate carrier (RFC), resulting in significant in vitro antitumor activity toward FRα-expressing KB human tumor cells. " 09/10/2015 - "The selectivity of these compounds for PCFT and for FRα and β over the ubiquitously expressed reduced folate carrier is a paradigm for selective tumor targeting. " 04/01/2008 - "Other mechanisms to explain the role of reduced folate carrier in cancer." 12/01/2006 - "Reduced folate carrier gene G80A polymorphism is associated with an increased risk of gastroesophageal cancers in a Chinese population."
2.	Osteosarcoma (Osteogenic Sarcoma) 07/24/2014 - "In this study, the relationship between reduced folate carrier (RFC) gene expression and intracellular drug concentration in MTX-resistant osteosarcoma cells (Saos-2) was investigated. " 05/01/2009 - "DHFR and Reduced folate carrier 1 (RFC1) semiquantitative expression was analyzed in 34 primary and metastatic osteosarcoma tissues by real-time polymerase chain reaction. " 09/01/2008 - "Polymorphisms and methylation of the reduced folate carrier in osteosarcoma." 10/14/2004 - "Functional analysis of altered reduced folate carrier sequence changes identified in osteosarcomas." 02/01/2003 - "Decreased reduced folate carrier (RFC) expression has been shown in approximately half of osteosarcomas at diagnosis. "
3.	Rheumatoid Arthritis 06/01/2015 - "Reduced folate carrier 1 gene expression levels are correlated with methotrexate efficacy in Japanese patients with rheumatoid arthritis." 01/01/2013 - "A single nucleotide polymorphism of reduced folate carrier 1 predicts methotrexate efficacy in Japanese patients with rheumatoid arthritis." 11/01/2004 - "Contribution of common polymorphisms in reduced folate carrier and gamma-glutamylhydrolase to methotrexate polyglutamate levels in patients with rheumatoid arthritis." 02/01/2020 - "The objective was to explore the association of methylene tetrahydrofolate reductase (MTHFR) C667T and A1298C and reduced folate carrier 1 (RFC-1) A80G single nucleotide polymorphisms (SNP) with rheumatoid arthritis (RA) and efficacy and toxicity of methotrexate (MTX) treatment in Chinese Han patients in Henan, China. " 08/01/1999 - "To investigate the expression of folate receptors (FR) and reduced folate carrier (RFC) and determine their relevance to methotrexate (MTX) transport in synovial mononuclear cells (SMC) from patients with rheumatoid arthritis (RA). "
4.	Malignant Mesothelioma 05/01/2013 - "Reduced folate carrier and folylpolyglutamate synthetase, but not thymidylate synthase predict survival in pemetrexed-treated patients suffering from malignant pleural mesothelioma." 04/01/2013 - "We examined whether the novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate, compound 2, might be an effective treatment for malignant pleural mesothelioma (MPM), reflecting its selective membrane transport by the proton-coupled folate transport (PCFT) over the reduced folate carrier (RFC). "
5.	Thrombosis (Thrombus) 10/14/2005 - "G80A reduced folate carrier SNP modulates cellular uptake of folate and affords protection against thrombosis via a non homocysteine related mechanism."

Related Drugs and Biologics

1.	Folic Acid (Vitamin M)
2.	Folic Acid Antagonists
3.	Methotrexate (Mexate)
4.	Homocysteine
5.	pyrimidine
6.	Sulfasalazine (Azulfidine)
7.	Protons (Proton)
8.	Methylenetetrahydrofolate Reductase (NADPH2) (Methylenetetrahydrofolate Reductase)
9.	Proton-Coupled Folate Transporter
10.	Tetrahydrofolate Dehydrogenase (Dihydrofolate Reductase)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Maintenance Chemotherapy
4.	Autologous Transplantation