Folate Receptor 1

08/01/2023 - "Recent advances in using folate receptor 1 (FOLR1) for cancer diagnosis and treatment, with an emphasis on cancers that affect women."
01/01/2023 - "Folate receptor alpha (FRα), which is expressed in various cancers, is a potential therapeutic target. "
01/01/2022 - "Here, we describe TNB-928B, a fully human TCE that has a bivalent binding arm for folate receptor alpha (FRα) to selectively target FRα overexpressing tumor cells while avoiding the lysis of cells with low levels of FRα expression. "
01/01/2022 - "Folate receptor alpha (FRα) is overexpressed in various cancer entities while expression in normal tissue is limited. "
01/01/2022 - "Folate Receptor 1 (FOLR1) or FOLRα, predominantly expressed on epithelial cells, remains a principal target for drug discovery in several cancers, including prostate or ovarian. "

10/02/2017 - "Improved Intraoperative Detection of Ovarian Cancer by Folate Receptor Alpha Targeted Dual-Modality Imaging."
01/01/2023 - "Ovarian cancers frequently overexpress Folate Receptor alpha (FRα) and the soluble receptor (sFRα) is measurable in blood. "
01/01/2023 - "Folate receptor alpha in ovarian cancer tissue and patient serum is associated with disease burden and treatment outcomes."
01/01/2021 - "We then validated PAtrace in phantom, in vitro, and in vivo PA imaging environments for both spectral unmixing accuracy and targeting efficacy in a folate receptor alpha-positive ovarian cancer model. "
11/01/2020 - "Conversely, folate receptor alpha (FRα) is highly expressed on ovarian cancer cells, providing a compelling target for tumour selective delivery of virotherapies. "

04/01/2012 - "In patients with adenocarcinoma that underwent surgical resection, increased folate receptor alpha expression was associated with improved overall survival (Hazard Ratio 0.39, 95% CI 0.18-0.85). "
01/01/2018 - "The goal of this study is to optimize the image quality of folate receptor alpha (FRα) targeted IMI for pulmonary adenocarcinomas by modifying emission data. "
06/06/2017 - "Expression status of folate receptor alpha is a predictor of survival in pancreatic ductal adenocarcinoma."
05/01/2012 - "High expression of folate receptor alpha in lung cancer correlates with adenocarcinoma histology and EGFR [corrected] mutation."
04/01/2012 - "While 74% of adenocarcinomas were positive for folate receptor alpha expression, our results found that only 13% of squamous cell carcinomas were FRA positive (p<0.0001). "

05/01/1999 - "The colon adenocarcinoma C26, carrying two endogenous tumor-associated antigens (TAA) recognized by CTL, has been transduced with the gene coding for the human folate receptor alpha (FR alpha) as an additional antigen in order to study the efficacy of vaccination against a tumor expressing multiple antigens. "

10/01/2019 - "The efficacy of targeting strategy with FA moieties was demonstrated using the augmented cellular uptake of the FA-conjugated system on overexpressed folate receptor alpha (FRα) cells (MDA-MB-468 breast cancer cell line). "
11/01/2017 - "Folate receptor alpha (FOLR1) has been identified as a potential prognostic and therapeutic target in breast cancer. "
01/01/2015 - "Folate Receptor Alpha Immunohistochemistry in Cytology Specimens of Metastatic Breast Carcinoma."
01/01/2012 - "Folate receptor alpha (FRA) expression in breast cancer: identification of a new molecular subtype and association with triple negative disease."
05/31/2016 - "Intraoperative imaging of folate receptor alpha positive ovarian and breast cancer using the tumor specific agent EC17."