Uromodulin

A glycosyl-phosphatidyl-inositol (GPI) - anchored membrane protein found on the thick ascending limb of the LOOP OF HENLE. The cleaved form of the protein is found abundantly in URINE.

Also Known As:

Networked: 335 relevant articles (4 outcomes, 45 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Rampoldi, Luca: 11 articles (10/2015 - 12/2004)
2.	Bleyer, Anthony J: 10 articles (10/2015 - 07/2003)
3.	Devuyst, Olivier: 8 articles (11/2015 - 08/2010)
4.	Lhotta, Karl: 6 articles (12/2014 - 01/2007)
5.	Kumar, Satish: 6 articles (03/2014 - 03/2004)
6.	Wu, Xue-Ru: 6 articles (04/2013 - 04/2002)
7.	Parsons, C Lowell: 5 articles (08/2015 - 12/2007)
8.	Fox, Caroline S: 5 articles (08/2014 - 06/2009)
9.	Aigner, Bernhard: 5 articles (04/2014 - 11/2009)
10.	Wolf, Eckhard: 5 articles (04/2014 - 11/2009)

Related Diseases

1.	Kidney Diseases (Kidney Disease) 02/01/2012 - "Follow-up studies stimulated by findings from genome-wide association studies of kidney disease are already yielding promising results, such as the identification of an association between urinary uromodulin levels and incident CKD. " 11/01/2015 - "The study of Garimella et al. adds elements into the debate, by suggesting that, in elderly adults, low urinary uromodulin concentrations in spot urine identify people at risk of progressive kidney disease and mortality above and beyond established markers of kidney disease. " 01/01/2014 - "Uromodulin retention in thick ascending limb of Henle's loop affects SCD1 in neighboring proximal tubule: renal transcriptome studies in mouse models of uromodulin-associated kidney disease." 01/01/2013 - "Recent studies have suggested that uromodulin may play a role in chronic kidney diseases. " 01/01/2012 - "In recent genetic association studies, common variants including rs12917707 in the UMOD locus have shown strong evidence of association with eGFR, prevalent and incident chronic kidney disease and uromodulin urinary concentration in general population cohorts. "
2.	Interstitial Cystitis (Interstitial Cystitis, Chronic) 09/01/1996 - "Urinary Tamm-Horsfall protein levels in 28 women with interstitial cystitis were statistically significantly greater than those in 25 female controls. " 07/01/2011 - "A multi-site study confirms abnormal glycosylation in the Tamm-Horsfall protein of patients with interstitial cystitis." 11/01/1992 - "Our study does not confirm the Tamm-Horsfall protein as permeating either the bladder epithelium in interstitial cystitis or bowel mucosa in enterocystoplasty. " 05/01/2013 - "To identify and characterise Tamm-Horsfall protein (THP)-associated metabolites present in patients with interstitial cystitis (IC). " 07/01/2011 - "These multisite data validate that abnormal glycosylation of Tamm-Horsfall protein occurs in patients with interstitial cystitis and may have a role in interstitial cystitis causation."
3.	Proteinuria 01/01/2013 - "We found that lower baseline urinary uromodulin levels (P = 0.03) and higher time-average proteinuria (P = 0.04) were risk factors for rapid eGFR decline in a follow-up subgroup of the IgA nephropathy cohort. " 09/01/2008 - "He presented with mild proteinuria (albuminuria/creatininuria 19 mg/mmol) and decreased glomerular filtration rate (GFR) (79 ml/min per 1.73 m(2) body surface area) leading to kidney biopsy, which showed nephronophthisis-like lesions, but neither NPHP1 gene deletion nor UMOD (uromodulin) mutation were identified. " 01/01/1996 - "Acidotic animals developed tubular proteinuria (16.4 +/- 2.6 mg/day after 2 weeks of acidosis vs. 2.9 +/- 0.3 mg/day at baseline; p < 0.001), and the pattern of immunohistochemical staining for Tamm-Horsfall protein suggested tubular injury. " 01/01/2001 - "The following parameters were examined: urinalysis and urine sediment, clearance of creatinine, tubular resorption, ultrasound of kidneys, 24 hrs proteinuria (PU) and urine concentration of albumine, transferine, alpha-1-microglobuline and Tamm-Horsfall protein. " 09/01/1997 - "Other clinical patterns, such as glomerular proteinuria, the presence of intact immunoglobulin and Tamm Horsfall protein can also be detected. "
4.	Nephrolithiasis 01/01/1984 - "The results of these studies indicate that autoimmune responses to Tamm-Horsfall protein may occur after exposure to Tamm-Horsfall protein by intravenous challenge in rabbits, and by urinary reflux in pigs, as well as in recurrent nephrolithiasis in man.(ABSTRACT TRUNCATED AT 250 WORDS)" 07/28/1983 - "These studies suggest that autoimmune responses to Tamm-Horsfall protein may occur after exposure to Tamm-Horsfall protein by intravenous challenge, urinary reflux, or recurrent nephrolithiasis. " 07/28/1983 - "Third, in human studies, 12 of 49 patients with recurrent nephrolithiasis demonstrated abnormal elevations in anti-Tamm-Horsfall protein antibody; 13 of 49 had an abnormality in one of two assays of cell-mediated immunity to Tamm-Horsfall protein as compared with 0 of the normal control subjects. " 10/01/2001 - "Although staining for Tamm-Horsfall protein was evident in the papillae of rats with nephrolithiasis, the site of Tamm-Horsfall protein synthesis remained cells of the thick ascending limbs of the loop of Henle." 10/01/2001 - "Tamm-Horsfall protein from rats with nephrolithiasis was biochemically similar to that from normal rats. "
5.	Interstitial Nephritis (Tubulointerstitial Nephritis) 01/01/1984 - "The present studies were designed to investigate the immunopathogenic role of Tamm-Horsfall protein in a rabbit model of tubulointerstitial nephritis, and in a swine model of reflux nephropathy. " 03/01/2000 - "Recently, urinary Tamm-Horsfall protein has been implicated in tubulointerstitial nephritis." 05/01/1999 - "Binding of human neutrophils to cell-surface anchored Tamm-Horsfall glycoprotein in tubulointerstitial nephritis." 01/01/1990 - "Tubulointerstitial nephritis induced by Tamm-Horsfall protein sensitization in guinea pigs." 01/01/1987 - "Tubulointerstitial nephritis by Tamm-Horsfall glycoprotein or egg white component."

Related Drugs and Biologics

1.	4-phenylbutyric acid (Buphenyl)
2.	Creatinine
3.	Colchicine
4.	Antibodies
5.	Antigens
6.	Uromodulin
7.	Autoantibodies
8.	Calcium Oxalate
9.	Antigen-Antibody Complex (Immune Complex)
10.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Lithotripsy (Extracorporeal Shockwave Lithotripsy)
2.	Kidney Transplantation
3.	Drug Therapy (Chemotherapy)
4.	Transplants (Transplant)
5.	Homologous Transplantation (Allograft)