Riboswitch

Part of a MESSENGER RNA molecule that undergoes a conformation change upon binding a specific metabolite or other small molecule thereby regulating the messenger RNA's transcription, post-transcriptional processing, transport, translation, or stability in response to varying levels of the metabolite or other small molecule.

Also Known As:

Networked: 38 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Lafontaine, Daniel A: 3 articles (11/2021 - 04/2010)
2.	Fortier, Louis-Charles: 2 articles (11/2021 - 04/2010)
3.	Hartig, Jörg S: 2 articles (01/2019 - 10/2015)
4.	Ferré-D'Amaré, Adrian R: 2 articles (09/2014 - 12/2011)
5.	Mulhbacher, Jérôme: 2 articles (10/2010 - 04/2010)
6.	Allen, Michael J: 1 article (12/2022)
7.	Bell, Ashley G: 1 article (12/2022)
8.	Bolaños, Luis M: 1 article (12/2022)
9.	Buchholz, Holger H: 1 article (12/2022)
10.	Michelsen, Michelle L: 1 article (12/2022)

Related Diseases

1.	Dehydration (Water Stress) 09/02/2014 - "Replacement of Li(+) and Mg(2+) needed for growth of crystals of a tRNA-riboswitch-protein complex with Sr(2+), coupled with dehydration, dramatically improved the resolution limit (8.5-3.2 Å) and data quality, enabling structure determination. " 10/09/2012 - "Dehydration from conserved stem regions is fundamental for ligand-dependent conformational transition of the adenine-specific riboswitch."
2.	Infections 11/20/2012 - "We demonstrate the utility of riboswitches, and for the first time show that riboswitches can be used to functionally control a bacterial gene that is critical to the ability of a pathogen to cause disease, during intracellular infection. " 11/20/2012 - "Riboswitch-mediated control of FTN_0818 rescued the growth of an FTN_0818 mutant in minimal medium and during macrophage infection. " 01/01/2023 - "Our results suggest that the riboswitch has a minimal contribution in isolation, while genome stability and translational promotion have similar contributions in the establishment phase of infection. " 11/12/2021 - "difficile during infection, suggesting that targeting guanine riboswitches with analogues could be a viable therapeutic strategy." 11/12/2021 - "Inactivation of the riboswitch-controlled GMP synthase GuaA in Clostridioides difficile is associated with severe growth defects and poor infectivity in a mouse model of infection."
3.	Starvation 01/01/2018 - "RNA structures called tandem riboswitches allow bacteria to employ complex logical operations in response to nutrient starvation." 01/01/2014 - "Operon-2 was highly up-regulated upon corrinoid starvation both at the transcriptional (346-fold) and proteomic level (46-fold on average), in line with the presence of an upstream cobalamin riboswitch. " 01/01/2019 - "The optimized orthogonal riboswitch was then integrated downstream of four endogenous stress promoters, responsive to phosphate starvation, hyperosmotic stress, redox stress, and carbon starvation. " 01/01/2011 - "We also showed, by using riboswitches that activate transcription in conditions of tyrosine or methionine starvation, that the effect of transcriptional de-repression of the leuC construct on the accumulation of Leu(+) mutations was independent of selection. "
4.	Genomic Instability 01/01/2023 - "Our results suggest that the riboswitch has a minimal contribution in isolation, while genome stability and translational promotion have similar contributions in the establishment phase of infection. " 01/01/2023 - "MiR-122 has at least three roles in the HCV life cycle: it acts as an RNA chaperone, or 'riboswitch', allowing formation of the viral internal ribosomal entry site; it provides genome stability; and promotes viral translation. " 01/01/2021 - "Specifically, resistance-associated variants promoted riboswitch activity, genome stability, or positive-strand viral RNA synthesis, all in the absence of miR-122. "
5.	Staphylococcal Infections 12/20/2011 - "Recent rational drug design efforts focused on select riboswitch classes have yielded a small number of candidate antibiotic compounds, including one active in a mouse model of Staphylococcus aureus infection. " 01/01/2016 - "De Novo Guanine Biosynthesis but Not the Riboswitch-Regulated Purine Salvage Pathway Is Required for Staphylococcus aureus Infection In Vivo."

Related Drugs and Biologics

1.	Transfer RNA (tRNA)
2.	Proteins (Proteins, Gene)
3.	RNA (Ribonucleic Acid)
4.	Ligands
5.	Guanine
6.	MicroRNAs (MicroRNA)
7.	Catalytic RNA (Ribozymes)
8.	Flavin Mononucleotide (FMN)
9.	Enzymes
10.	Anti-Bacterial Agents (Antibiotics)

Related Therapies and Procedures

1.	Thermometers
2.	Therapeutics