5-Lipoxygenase-Activating Proteins

Scaffolding proteins that play an important role in the localization and activation of 5-LIPOXYGENASE.

Also Known As:

5-LO-Activating Protein; 5-Lipoxygenase-Activating Protein; Arachidonate 5-Lipoxygenase Activating Protein; Arachidonate 5-Lipoxygenase Activating Proteins; 5 LO Activating Protein; 5 Lipoxygenase Activating Protein; 5 Lipoxygenase Activating Proteins; Arachidonate 5 Lipoxygenase Activating Protein; Arachidonate 5 Lipoxygenase Activating Proteins

Networked: 95 relevant articles (3 outcomes, 21 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843

Experts

1.	Gabrielsen, Anders: 4 articles (10/2022 - 05/2006)
2.	Evans, Jilly F: 4 articles (12/2009 - 09/2004)
3.	Haeggström, Jesper Z: 3 articles (12/2010 - 05/2006)
4.	Bain, Gretchen: 3 articles (12/2009 - 10/2009)
5.	Hutchinson, John H: 3 articles (12/2009 - 10/2009)
6.	Hakonarson, Hakon: 3 articles (05/2006 - 05/2005)
7.	Helgadottir, Anna: 3 articles (01/2006 - 05/2005)
8.	Stefansson, Kari: 3 articles (01/2006 - 05/2005)
9.	Garkaviy, Pavlo: 2 articles (10/2022 - 10/2021)
10.	Knöchel, Jane: 2 articles (10/2022 - 10/2021)

Related Diseases

1.	Stroke (Strokes) 10/01/2018 - "The objective of this study was to evalutate the relationship between 5-lipoxygenase-activating protein gene (ALOX5AP) -rs17222919-1316T/G polymorphisms and the risk of stroke. " 07/01/2014 - "Previous studies have implicated that two at-risk haplotypes (HapA and HapB) of gene-encoding 5-lipoxygenase-activating protein (ALOX5AP) were significantly associated with stroke. " 03/01/2005 - "We recently reported a linkage and association study of MI and stroke that yielded a genetic variant, HapA, in the gene encoding 5-lipoxygenase-activating protein (ALOX5AP), that associates with both diseases in Iceland. " 10/01/2018 - "Association between the polymorphism (rs17222919, -1316T/G) of 5-lipoxygenase-activating protein gene (ALOX5AP) and the risk of stroke: A meta analysis." 01/01/2015 - "5-lipoxygenase-activating protein gene (ALOX5AP) has been recognized as a susceptibility gene for stroke. "
2.	Myocardial Infarction 01/01/2020 - "ASSOCIATION BETWEEN SINGLE POLYMORPHISM IN THE LOCUS RS17216473 OF THE GENE THAT ENCODES 5-LIPOXYGENASE-ACTIVATING PROTEIN AND RISK OF MYOCARDIAL INFARCTION." 11/01/2008 - "Genetic variation in the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) is associated with myocardial infarction in the German population." 02/01/2007 - "In this sample from central Europe, specific polymorphisms in the gene for 5-lipoxygenase-activating protein were not associated with myocardial infarction, a result contrasting previous positive findings." 02/01/2007 - "Haplotypes based on polymorphisms in the gene encoding 5-lipoxygenase-activating protein have been linked with susceptibility to myocardial infarction in Iceland and the United Kingdom. " 02/01/2007 - "No association of polymorphisms in the gene encoding 5-lipoxygenase-activating protein and myocardial infarction in a large central European population."
3.	Pain (Aches) 08/01/2007 - "This study compares the efficacy of intraplantar administration of indomethacin (a non-selective inhibitor of cyclooxygenase) and MK886 (an inhibitor of 5-lipoxygenase-activating protein), separately or in combination to produce preemptive analgesia in a model of surgical incisional pain in male Wistar rats. "
4.	Asthma (Bronchial Asthma) 11/01/2014 - "Targeting 5-lipoxygenase-activating protein in asthma and chronic obstructive pulmonary disease." 02/01/2014 - "This study evaluated the effects of an oral 5-lipoxygenase-activating protein (FLAP) inhibitor, GSK2190915, in patients with asthma and elevated sputum neutrophils. " 03/01/2014 - "This double-blind, placebo-controlled, five-way crossover study investigated the dose response and duration of action of a 5-lipoxygenase-activating protein inhibitor, GSK2190915, to inhibit EIB in subjects with asthma. " 12/01/2013 - "Addition of a 5-lipoxygenase-activating protein inhibitor to an inhaled corticosteroid (ICS) or an ICS/long-acting beta-2-agonist combination in subjects with asthma." 05/17/2013 - "GSK2190915 is a high affinity 5-lipoxygenase-activating protein inhibitor being developed for the treatment of asthma. "
5.	Ischemic Stroke 01/10/2014 - "Previous studies have indicated that the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene SG13S114 polymorphism is associated with risk of ischemic stroke (IS), but the results remain inconclusive even in Chinese population. " 01/01/2019 - "In recent years, there has been substantial research evaluating the relationship between arachidonate 5-lipoxygenase-activating protein (ALOX5AP) polymorphisms and ischemic stroke (IS). " 04/01/2014 - "Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene rs4073259 polymorphism not associated with ischemic stroke in the northeastern Chinese Han population." 01/10/2014 - "The arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene SG13S114 polymorphism and ischemic stroke in Chinese population: a meta-analysis." 09/01/2011 - "Variants of the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and risk of ischemic stroke in Han Chinese of eastern China."

Related Drugs and Biologics

1.	Type 4 Cyclic Nucleotide Phosphodiesterases
2.	MK-886
3.	Enzymes
4.	Indomethacin (Indometacin)
5.	AZD5718
6.	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
7.	Leukotrienes
8.	Proteins (Proteins, Gene)
9.	Arachidonate 5-Lipoxygenase (5 Lipoxygenase)
10.	Messenger RNA (mRNA)

Related Therapies and Procedures

1.	Analgesia
2.	Therapeutics