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5-Lipoxygenase-Activating Proteins

Subscribe to New Research on 5-Lipoxygenase-Activating Proteins

Scaffolding proteins that play an important role in the localization and activation of 5-LIPOXYGENASES.

Also Known As:

5-LO-Activating Protein; 5-Lipoxygenase-Activating Protein; Arachidonate 5-Lipoxygenase Activating Protein; Arachidonate 5-Lipoxygenase Activating Proteins; 5 LO Activating Protein; 5 Lipoxygenase Activating Protein; 5 Lipoxygenase Activating Proteins; Arachidonate 5 Lipoxygenase Activating Protein; Arachidonate 5 Lipoxygenase Activating Proteins

Networked: 81 relevant articles (2 outcomes, 16 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Evans, Jilly F: 4 articles (12/2009 - 09/2004)
2.	Haeggström, Jesper Z: 3 articles (12/2010 - 05/2006)
3.	Bain, Gretchen: 3 articles (12/2009 - 10/2009)
4.	Hutchinson, John H: 3 articles (12/2009 - 10/2009)
5.	Hakonarson, Hakon: 3 articles (05/2006 - 05/2005)
6.	Stefansson, Kari: 3 articles (01/2006 - 05/2005)
7.	Helgadottir, Anna: 3 articles (01/2006 - 05/2005)
8.	Li, Na: 2 articles (07/2015 - 12/2009)
9.	Wang, Qing: 2 articles (07/2014 - 05/2005)
10.	Norris, V: 2 articles (02/2014 - 02/2013)

Related Diseases

1.	Stroke (Strokes) 07/01/2014 - "Previous studies have implicated that two at-risk haplotypes (HapA and HapB) of gene-encoding 5-lipoxygenase-activating protein (ALOX5AP) were significantly associated with stroke. " 01/10/2014 - "Previous studies have indicated that the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene SG13S114 polymorphism is associated with risk of ischemic stroke (IS), but the results remain inconclusive even in Chinese population. " 03/01/2005 - "We recently reported a linkage and association study of MI and stroke that yielded a genetic variant, HapA, in the gene encoding 5-lipoxygenase-activating protein (ALOX5AP), that associates with both diseases in Iceland. " 04/01/2014 - "Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene rs4073259 polymorphism not associated with ischemic stroke in the northeastern Chinese Han population." 01/10/2014 - "The arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene SG13S114 polymorphism and ischemic stroke in Chinese population: a meta-analysis."
2.	Pain (Aches) 08/01/2007 - "This study compares the efficacy of intraplantar administration of indomethacin (a non-selective inhibitor of cyclooxygenase) and MK886 (an inhibitor of 5-lipoxygenase-activating protein), separately or in combination to produce preemptive analgesia in a model of surgical incisional pain in male Wistar rats. "
3.	Myocardial Infarction 11/01/2008 - "Genetic variation in the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) is associated with myocardial infarction in the German population." 02/01/2007 - "In this sample from central Europe, specific polymorphisms in the gene for 5-lipoxygenase-activating protein were not associated with myocardial infarction, a result contrasting previous positive findings." 02/01/2007 - "Haplotypes based on polymorphisms in the gene encoding 5-lipoxygenase-activating protein have been linked with susceptibility to myocardial infarction in Iceland and the United Kingdom. " 02/01/2007 - "No association of polymorphisms in the gene encoding 5-lipoxygenase-activating protein and myocardial infarction in a large central European population." 01/01/2006 - "Variants of the gene ALOX5AP (also known as FLAP) encoding arachidonate 5-lipoxygenase activating protein are known to be associated with risk of myocardial infarction. "
4.	Asthma (Bronchial Asthma) 02/01/2014 - "This study evaluated the effects of an oral 5-lipoxygenase-activating protein (FLAP) inhibitor, GSK2190915, in patients with asthma and elevated sputum neutrophils. " 03/01/2014 - "This double-blind, placebo-controlled, five-way crossover study investigated the dose response and duration of action of a 5-lipoxygenase-activating protein inhibitor, GSK2190915, to inhibit EIB in subjects with asthma. " 12/01/2013 - "Addition of a 5-lipoxygenase-activating protein inhibitor to an inhaled corticosteroid (ICS) or an ICS/long-acting beta-2-agonist combination in subjects with asthma." 02/01/2013 - "The 5-lipoxygenase-activating protein inhibitor, GSK2190915, attenuates the early and late responses to inhaled allergen in mild asthma." 01/01/2013 - "GSK2190915 is a high affinity 5-lipoxygenase-activating protein inhibitor being developed for the treatment of asthma. "
5.	Cardiovascular Diseases (Cardiovascular Disease) 03/01/2006 - "Arachidonate 5-lipoxygenase activating protein (ALOX5AP) gene is involved in the pathogenesis of atherosclerotic cardiovascular disease (CVD). " 07/01/2006 - "Human genetic studies as well as disruption of the 5-LO gene in mouse models of hyperlipidemia revealed that 5-LO and 5-LO-activating protein are associated with risks of human cardiovascular disease, and that this cascade plays an important role in aortic aneurysm pathogenesis through leukotriene-mediated inflammatory chemokine production. " 09/01/2004 - "Genetic studies have associated 5-LO and its accessory protein, 5-LO-activating protein, with cardiovascular disease, myocardial infarction and stroke. " 04/17/2009 - "MK-886, an inhibitor of the 5-lipoxygenase-activating protein (FLAP), potently suppresses leukotriene biosynthesis in intact cells and is frequently used to define a role of the 5-lipoxygenase (EC 1.13.11.34) pathway in cellular or animal models of inflammation, allergy, cancer, and cardiovascular disease. "

Related Drugs and Biologics

1.	Enzymes
2.	Type 4 Cyclic Nucleotide Phosphodiesterases
3.	Indomethacin (Indometacin)
4.	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
5.	Arachidonate 5-Lipoxygenase (5 Lipoxygenase)
6.	Leukotrienes
7.	Messenger RNA (mRNA)
8.	Proteins (Proteins, Gene)
9.	Biological Markers (Surrogate Marker)
10.	Insulin Receptor Substrate Proteins

Related Therapies and Procedures

1.	Analgesia