Purinergic Agents

Compounds that act on PURINERGIC RECEPTORS or influence the synthesis, storage, uptake, metabolism, or release of purinergic transmitters.

Also Known As:

Purinergic Effect; Purinergic Effects; Agents, Purinergic; Effect, Purinergic; Effects, Purinergic

Networked: 10 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Chemical Actions and Uses
- Pharmacologic Actions: 160
  - Molecular Mechanisms of Pharmacological Action: 24
    - Neurotransmitter Agents: 13181
      - Purinergic Agents: 10
        Purinergic Agonists: 39
        Purinergic Antagonists: 16
  - Physiological Effects of Drugs: 1
    - Neurotransmitter Agents: 13181
      - Purinergic Agents: 10
        Purinergic Agonists: 39
        Purinergic Antagonists: 16

Experts

1.	Burnstock, Geoffrey: 2 articles (01/2017 - 01/2014)
2.	Alter, Christina: 1 article (02/2020)
3.	Bartoszewski, Rafal: 1 article (02/2020)
4.	Bulinska, Alicja: 1 article (02/2020)
5.	Chlopicki, Stefan: 1 article (02/2020)
6.	Friebe, Daniela: 1 article (02/2020)
7.	Jablonska, Patrycja: 1 article (02/2020)
8.	Jasztal, Agnieszka: 1 article (02/2020)
9.	Kutryb-Zajac, Barbara: 1 article (02/2020)
10.	Lango, Romuald: 1 article (02/2020)

Related Diseases

1.	Mania (Manias) 12/15/2023 - "Evaluating the purinergic effects of existing agents and validating purine dysregulation may improve diagnosis and treatment in bipolar mania and epilepsy and provide specific targets for drug development." 08/01/2008 - "This study aimed to evaluate the efficacy and tolerability of the purinergic agents allopurinol and dipyridamole combined with lithium in bipolar mania. " 08/01/2008 - "A double-blind, randomized, placebo-controlled 4-week study on the efficacy and safety of the purinergic agents allopurinol and dipyridamole adjunctive to lithium in acute bipolar mania."
2.	Chronic Renal Insufficiency 02/01/2012 - "Here we sought to measure purinergic effects on vascular calcification and initially found that Up(4)A plasma concentrations are increased in patients with chronic kidney disease. " 07/15/2013 - "Direct real-time measurements of purinergic agents and reactive oxygen species concentrations have been of great value in understanding the functional roles of these substances in a number of diseases including chronic kidney disease and hypertension. "
3.	Atherosclerosis 01/01/2014 - "The pathophysiology of blood vessels and therapeutic potential of purinergic agents in diseases, including hypertension, atherosclerosis, ischemia, thrombosis and stroke, diabetes, and migraine, is discussed. " 01/01/2017 - "Other investigations are in progress for the use of purinergic agents for the treatment of osteoporosis, myocardial infarction, irritable bowel syndrome, epilepsy, atherosclerosis, depression, autism, diabetes, and cancer."
4.	Hypertension (High Blood Pressure) 07/15/2013 - "Direct real-time measurements of purinergic agents and reactive oxygen species concentrations have been of great value in understanding the functional roles of these substances in a number of diseases including chronic kidney disease and hypertension. " 01/01/2014 - "The pathophysiology of blood vessels and therapeutic potential of purinergic agents in diseases, including hypertension, atherosclerosis, ischemia, thrombosis and stroke, diabetes, and migraine, is discussed. "
5.	Epilepsy (Aura) 12/15/2023 - "Evaluating the purinergic effects of existing agents and validating purine dysregulation may improve diagnosis and treatment in bipolar mania and epilepsy and provide specific targets for drug development." 01/01/2017 - "Other investigations are in progress for the use of purinergic agents for the treatment of osteoporosis, myocardial infarction, irritable bowel syndrome, epilepsy, atherosclerosis, depression, autism, diabetes, and cancer."

Related Drugs and Biologics

1.	Lithium
2.	Dipyridamole (Persantine)
3.	Allopurinol (Remid)
4.	Adenosine Triphosphate (ATP)
5.	Reactive Oxygen Species (Oxygen Radicals)
6.	Nucleotides
7.	Caffeine (No Doz)
8.	Adenosine (Adenocard)
9.	purine

Related Therapies and Procedures

1.	Punctures