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GPI-Linked Proteins

Subscribe to New Research on GPI-Linked Proteins

A subclass of lipid-linked proteins that contain a GLYCOSYLPHOSPHATIDYLINOSITOL LINKAGE which holds them to the CELL MEMBRANE.

Also Known As:

GPI-Linked Membrane Proteins; Glycosylphosphatidylinositol Linked Proteins; GPI Linked Membrane Proteins; GPI Linked Proteins; Linked Proteins, Glycosylphosphatidylinositol; Membrane Proteins, GPI-Linked; Proteins, GPI-Linked; Proteins, GPI-Linked Membrane; Proteins, Glycosylphosphatidylinositol Linked

Networked: 24 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - Glycoproteins: 18176
    - Membrane Glycoproteins: 1848
      - GPI-Linked Proteins: 24
        megakaryocyte potentiating factor: 431
        placental alkaline phosphatase: 418
        Glypicans: 413
        Uromodulin: 335
        CD55 Antigens: 218
        CD14 Antigens: 92
        CD59 Antigens: 84
        Ephrin-A1: 69
        Ephrin-A5: 28
        dipeptidase 1: 22
        Carbonic Anhydrase IV: 20
        matrix metalloproteinase 25: 19
        carboxypeptidase M: 17
        CD24 Antigens: 17
        Ciliary Neurotrophic Factor Receptor alpha Subunit: 17
        Matrix Metalloproteinase 17: 16
        Ephrin-A3: 14
        pantetheinase: 13
        Ephrin-A2: 12
        Ephrin-A4: 10
        Glial Cell Line-Derived Neurotrophic Factor Receptors: 10
        ADP-ribosyl cyclase 2: 5
        limbic system-associated membrane protein: 5
        neurotrimin: 5
        Contactins: 4
        human CD160 protein: 1
        GPI-Anchored Folate Receptors
        human ACHE protein
        human ALPI protein
        human ALPPL2 protein
        human ART1 protein
        human ART3 protein
        human BST2 protein
        human CD109 protein
        human CD177 protein
        human CEACAM5 protein
        human CEACAM6 protein
        human CEACAM7 protein
        human CEACAM8 protein
        human FCGR3B protein
        human GAS1 protein
        human GML protein
        human GP2 protein
        human HFE2 protein
        human Hyal2 protein
        human ITLN1 protein
        human LY6D protein
        human LY6E protein
        human LY6K protein
        human LYNX1 protein
        human LYPD1 protein
        human LYPD3 protein
        human MDGA1 protein
        human MDGA2 protein
        human NEGR1 protein
        human NRN1 protein
        human NT5E protein
        human NTNG1 protein
        human NTNG2 protein
        human OPCML protein
        human OTOA protein
        human PRND protein
        human PRSS21 protein
        human PSCA protein
        human RECK protein
        human RGMA protein
        human RTN4R protein
        human RTN4RL1 protein
        human RTN4RL2 protein
        human SEMA7A protein
        human SPRN protein
        human TECTA protein
        human TECTB protein
        human TNFRSF10C protein
        human ULBP1 protein
        human ULBP2 protein
        human ULBP3 protein
        human VNN2 protein
        human VNN3 protein
        mouse Ache protein
        mouse Art3 protein
        mouse Cd160 protein
        mouse Gas1 protein
        mouse Gp2 protein
        mouse Hyal2 protein
        mouse Ly6d protein
        mouse Mfi2 protein
        mouse Nrn1 protein
        mouse Nt5e protein
        mouse Opcml protein
        mouse Otoa protein
        mouse Prnd protein
        mouse Prss21 protein
        mouse Psca protein
        mouse Reck protein
        mouse Rgma protein
        mouse Rtn4r protein
        mouse Tecta protein
        mouse TEX101 protein
        mouse Vnn3 protein
  - Membrane Proteins: 5300
    - Membrane Glycoproteins: 1848
      - GPI-Linked Proteins: 24
        megakaryocyte potentiating factor: 431
        placental alkaline phosphatase: 418
        Glypicans: 413
        Uromodulin: 335
        CD55 Antigens: 218
        CD14 Antigens: 92
        CD59 Antigens: 84
        Ephrin-A1: 69
        Ephrin-A5: 28
        dipeptidase 1: 22
        Carbonic Anhydrase IV: 20
        matrix metalloproteinase 25: 19
        carboxypeptidase M: 17
        CD24 Antigens: 17
        Ciliary Neurotrophic Factor Receptor alpha Subunit: 17
        Matrix Metalloproteinase 17: 16
        Ephrin-A3: 14
        pantetheinase: 13
        Ephrin-A2: 12
        Ephrin-A4: 10
        Glial Cell Line-Derived Neurotrophic Factor Receptors: 10
        ADP-ribosyl cyclase 2: 5
        limbic system-associated membrane protein: 5
        neurotrimin: 5
        Contactins: 4
        human CD160 protein: 1
        GPI-Anchored Folate Receptors
        human ACHE protein
        human ALPI protein
        human ALPPL2 protein
        human ART1 protein
        human ART3 protein
        human BST2 protein
        human CD109 protein
        human CD177 protein
        human CEACAM5 protein
        human CEACAM6 protein
        human CEACAM7 protein
        human CEACAM8 protein
        human FCGR3B protein
        human GAS1 protein
        human GML protein
        human GP2 protein
        human HFE2 protein
        human Hyal2 protein
        human ITLN1 protein
        human LY6D protein
        human LY6E protein
        human LY6K protein
        human LYNX1 protein
        human LYPD1 protein
        human LYPD3 protein
        human MDGA1 protein
        human MDGA2 protein
        human NEGR1 protein
        human NRN1 protein
        human NT5E protein
        human NTNG1 protein
        human NTNG2 protein
        human OPCML protein
        human OTOA protein
        human PRND protein
        human PRSS21 protein
        human PSCA protein
        human RECK protein
        human RGMA protein
        human RTN4R protein
        human RTN4RL1 protein
        human RTN4RL2 protein
        human SEMA7A protein
        human SPRN protein
        human TECTA protein
        human TECTB protein
        human TNFRSF10C protein
        human ULBP1 protein
        human ULBP2 protein
        human ULBP3 protein
        human VNN2 protein
        human VNN3 protein
        mouse Ache protein
        mouse Art3 protein
        mouse Cd160 protein
        mouse Gas1 protein
        mouse Gp2 protein
        mouse Hyal2 protein
        mouse Ly6d protein
        mouse Mfi2 protein
        mouse Nrn1 protein
        mouse Nt5e protein
        mouse Opcml protein
        mouse Otoa protein
        mouse Prnd protein
        mouse Prss21 protein
        mouse Psca protein
        mouse Reck protein
        mouse Rgma protein
        mouse Rtn4r protein
        mouse Tecta protein
        mouse TEX101 protein
        mouse Vnn3 protein
    - Lipid-Linked Proteins: 1
      - GPI-Linked Proteins: 24
        megakaryocyte potentiating factor: 431
        placental alkaline phosphatase: 418
        Glypicans: 413
        Uromodulin: 335
        CD55 Antigens: 218
        CD14 Antigens: 92
        CD59 Antigens: 84
        Ephrin-A1: 69
        Ephrin-A5: 28
        dipeptidase 1: 22
        Carbonic Anhydrase IV: 20
        matrix metalloproteinase 25: 19
        carboxypeptidase M: 17
        CD24 Antigens: 17
        Ciliary Neurotrophic Factor Receptor alpha Subunit: 17
        Matrix Metalloproteinase 17: 16
        Ephrin-A3: 14
        pantetheinase: 13
        Ephrin-A2: 12
        Ephrin-A4: 10
        Glial Cell Line-Derived Neurotrophic Factor Receptors: 10
        ADP-ribosyl cyclase 2: 5
        limbic system-associated membrane protein: 5
        neurotrimin: 5
        Contactins: 4
        human CD160 protein: 1
        GPI-Anchored Folate Receptors
        human ACHE protein
        human ALPI protein
        human ALPPL2 protein
        human ART1 protein
        human ART3 protein
        human BST2 protein
        human CD109 protein
        human CD177 protein
        human CEACAM5 protein
        human CEACAM6 protein
        human CEACAM7 protein
        human CEACAM8 protein
        human FCGR3B protein
        human GAS1 protein
        human GML protein
        human GP2 protein
        human HFE2 protein
        human Hyal2 protein
        human ITLN1 protein
        human LY6D protein
        human LY6E protein
        human LY6K protein
        human LYNX1 protein
        human LYPD1 protein
        human LYPD3 protein
        human MDGA1 protein
        human MDGA2 protein
        human NEGR1 protein
        human NRN1 protein
        human NT5E protein
        human NTNG1 protein
        human NTNG2 protein
        human OPCML protein
        human OTOA protein
        human PRND protein
        human PRSS21 protein
        human PSCA protein
        human RECK protein
        human RGMA protein
        human RTN4R protein
        human RTN4RL1 protein
        human RTN4RL2 protein
        human SEMA7A protein
        human SPRN protein
        human TECTA protein
        human TECTB protein
        human TNFRSF10C protein
        human ULBP1 protein
        human ULBP2 protein
        human ULBP3 protein
        human VNN2 protein
        human VNN3 protein
        mouse Ache protein
        mouse Art3 protein
        mouse Cd160 protein
        mouse Gas1 protein
        mouse Gp2 protein
        mouse Hyal2 protein
        mouse Ly6d protein
        mouse Mfi2 protein
        mouse Nrn1 protein
        mouse Nt5e protein
        mouse Opcml protein
        mouse Otoa protein
        mouse Prnd protein
        mouse Prss21 protein
        mouse Psca protein
        mouse Reck protein
        mouse Rgma protein
        mouse Rtn4r protein
        mouse Tecta protein
        mouse TEX101 protein
        mouse Vnn3 protein

Experts

1.	Hill, Anita: 2 articles (09/2013 - 11/2012)
2.	Hillmen, Peter: 2 articles (09/2013 - 01/2004)
3.	Bessler, M: 2 articles (10/2001 - 09/2001)
4.	Keller, P: 2 articles (10/2001 - 09/2001)
5.	Tao, Shandong: 1 article (01/2015)
6.	Chen, Yue: 1 article (01/2015)
7.	Song, Lixiao: 1 article (01/2015)
8.	Deng, Yuan: 1 article (01/2015)
9.	Yu, Liang: 1 article (01/2015)
10.	Canalejo, K: 1 article (04/2014)

Related Diseases

1.	Paroxysmal Hemoglobinuria (Paroxysmal Nocturnal Hemoglobinuria) 11/01/1999 - "PIGA is somatically mutated in blood cells from patients with paroxysmal nocturnal hemoglobinuria (PNH), leading to deficiency of GPI-linked proteins on the cell surface. " 10/01/1998 - "The PIG-A mutation and absence of glycosylphosphatidylinositol-linked proteins do not confer resistance to apoptosis in paroxysmal nocturnal hemoglobinuria." 09/25/1998 - "The identification of CD59-mediated signaling events may help explain why paroxysmal nocturnal hemoglobinuria patients, who are deficient in glycosylphosphatidylinositol-linked proteins including CD59, are susceptible to proliferative disorders." 04/01/2014 - "Paroxysmal nocturnal hemoglobinuria (PNH) is a hemolytic, clonal and acquired disorder of the hematopoietic stem cell with a deficiency of all glycophosphatidyl-inositol (GPI) linked proteins. " 09/12/2013 - "In paroxysmal nocturnal hemoglobinuria (PNH), hematopoietic cells lacking glycosylphosphatidylinositol (GPI)-linked proteins on their surface (GPI(neg)) exist alongside normal (GPI+) cells. "
2.	Hemolysis 06/01/2002 - "These animals have a discrete proportion of blood cells devoid of GPI-linked proteins, and although not anemic, they have evidence of hemolysis. " 01/01/2001 - "Absence of GPI-linked proteins from the surface of blood cells is characteristic of the PIG-A mutant (PNH) clone and is also accountable fo certain manifestations, such as intravascular hemolysis. " 01/01/2015 - "Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hematopoietic stem cell (HSC) disorder arising from a somatic mutation of the X-linked phosphatidylinositol glycan complementation class A gene (PIG-A) which leads to partial or complete deficiency of glycosyl-phosphatidylinositol (GPI)-linked membrane proteins and causes intravascular hemolysis. " 11/25/2008 - "Paroxysmal nocturnal hemoglobinuria is an acquired hematopoietic stem cell (HSC) disorder characterized by the partial or complete deficiency of glycosyl-phosphatidylinositol (GPI)-linked membrane proteins, which leads to intravascular hemolysis. " 11/01/2012 - "However, in patients with PNH, these 2 proteins, along with numerous other GPI-linked proteins, are absent from the cell surface of red cells, granulocytes, monocytes, and platelets, resulting in complement-mediated intravascular hemolysis and other complications. "
3.	Thrombosis (Thrombus) 01/01/2004 - "In Section I, Dr. Peter Hillmen outlines the recent findings in the pathogenesis of paroxysmal nocturnal hemoglobinuria (PNH), relating the biochemical defect (the lack of glycosylphosphatidylinositol [GPI]-linked proteins on the cell surface) to the clinical manifestations, particularly hemolysis (and its effects) and thrombosis. " 07/01/2007 - "PNH clones then fail to generate glycosylphosphatidylinositol (GPI) or to express a series of GPI-linked membrane proteins including complement-regulatory proteins, resulting in complement-mediated intravascular hemolysis and thrombosis. "
4.	Vesicular Stomatitis 10/01/1991 - "In contrast, cell surface interactions of the ectodomain of membrane-spanning proteins exemplified by the vesicular stomatitis virus G glycoprotein reduces their lateral diffusion coefficients by nearly 10-fold with respect to many GPI-linked proteins."
5.	Rare Diseases (Rare Disease) 08/01/2007 - "Paroxysmal nocturnal hemoglobinuria (PNH) is a rare disease caused by a somatic mutation of the PIGA gene, which results in the absence of the glycosylphosphatidylinositol-linked proteins necessary to protect cells from complement-mediated lysis. "

Related Drugs and Biologics

1.	Glycosylphosphatidylinositols (Glycosyl-Phosphatidylinositol)
2.	Proteins (Proteins, Gene)
3.	Complement System Proteins (Complement)
4.	Scavenger Receptors (Scavenger Receptor)
5.	Monomeric GTP-Binding Proteins
6.	GTP-Binding Proteins (G-Protein)
7.	src-Family Kinases
8.	Phosphotransferases (Kinase)
9.	Phosphatidylinositols (Phosphatidylinositol)
10.	Inositol (Myoinositol)