Inflammasomes

05/01/2015 - "Notably, Nlrp3 and caspase-1 knockout mice were more susceptible to infection than were the wild-type animals, suggesting that the Nlrp3-dependent inflammasomes contribute to host protection against P. "
03/11/2015 - "Concerted activation of the AIM2 and NLRP3 inflammasomes orchestrates host protection against Aspergillus infection."
04/01/2013 - "abortus infection than were wild-type animals, suggesting that multiple ASC-dependent inflammasomes contribute to host protection against infection. "
09/01/2012 - "Different inflammasomes have been demonstrated to respond to the same pathogen inducing a cooperative immune response accountable for the clearance of infection. "
10/07/2014 - "Recent studies indicated that Shigella deploy multiple mechanisms to stimulate NLR inflammasomes through type III secretion during infection. "

01/01/2015 - "The renoprotective functions of autophagy in epithelial renal cells and podocytes are mostly mediated by the clearance of altered mitochondria, which can activate inflammasomes and apoptosis, and the removal of protein aggregates, which might trigger inflammation and cell death. "
10/01/2014 - "Inflammasomes contribute to both the clearance of the pathogen as well as its pathogenesis - depending on the amount of inflammation triggered. "
08/01/2015 - "Recent studies have revealed functional roles of inflammasomes - particularly NAIP/NLRC4, NLRP6, and noncanonical caspase-4 (caspase-11) - within epithelial cells of the gut in mucosal immune defense, inflammation, and tumorigenesis. "
05/01/2015 - "Hence in this study we determine whether: a) ROS activated NLRP3 inflammasomes mediate hyperosmotic stress-induced inflammation in human corneal epithelial cells (HCECs); b) the ROS-NLRP3-IL-1β axis activation is associated with environment-induced DE. "
05/01/2014 - "There is abundant literature on ASC/TMS1, mostly under the name TMS1, in the epigenetic regulation of apoptosis and carcinogenesis, whereas the abbreviation ASC has been adopted from studies on the assembly of inflammasomes and stimulation of inflammation. "

07/01/2015 - "However, there is increasing attention being placed on genetic polymorphisms that are involved in the components of inflammasomes, and these have implications for innate immunity and the natural history of autoimmune diseases. "
07/01/2015 - "In this review, we discuss recent insight in the protective and detrimental roles of inflammasomes in selected infectious, autoinflammatory and autoimmune diseases, and cover clinically approved therapies that interfere with inflammasome signaling. "
05/01/2013 - "Inflammasomes are also known to be involved in the development of some human and animal autoimmune diseases. "
09/19/2011 - "[Danger signals and inflammasomes in autoinflammatory and autoimmune diseases]."
01/01/2009 - "Further understanding of inflammasomes and their role in innate immunity should provide new insights into the mechanisms of host defense and the pathogenesis of autoimmune diseases."

03/23/2012 - "Because inflammasomes contribute to the pathology of numerous chronic inflammatory diseases such as gout and diabetes, IL-1α antagonists may be beneficial in the treatment of these disorders."
01/01/2008 - "The number of known triggers that stimulate inflammasomes is rapidly rising, ranging from genetic mutations to microbial products, gout crystals, ultraviolet light and adjuvant chemicals. "
06/01/2014 - "p62 is required for activation of inflammasomes during acute inflammation in gout."
03/01/2010 - "Subsequently, inflammasomes have been implicated in the pathology of many common diseases, including cancer, gout and diabetes. "
12/01/2014 - "Inflammasomes are crucial initiators of sterile inflammation in other diseases such as rheumatoid arthritis and gout. "

07/01/2015 - "However, evidence for the role of inflammasomes in this process is still scarce and mainly derived from murine colitis associated tumour models. "
07/01/2013 - "A model to reconcile the conflicting results in the literature on the role of inflammasomes in experimental colitis will be discussed. "
05/15/2013 - "However, there are few drug candidates targeting inflammasomes for the treatment of colitis. "
01/01/2015 - "Inflammasomes have a direct and important role limiting colitis by directing effective immune responses against pathogenic bacterial infections in the intestine. "
01/01/2012 - "DAMPs and PAMPs, however, may also be required for maintaining intestinal epithelial barrier functions as demonstrated by the enhanced susceptibility for colitis development in mice deficient for the NLRP6 or NLRC4 sensors in inflammasomes in intestinal epithelial cells."