Serotonin 5-HT4 Receptor Antagonists

Drugs that bind to but do not activate SEROTONIN 5-HT4 RECEPTORS, thereby blocking the actions of SEROTONIN or SEROTONIN RECEPTOR AGONISTS.

Also Known As:

5-HT4 Antagonist; 5-HT4 Antagonists; 5 HT4 Antagonist; 5 HT4 Antagonists; Antagonist, 5-HT4; Antagonists, 5-HT4; Serotonin 5 HT4 Receptor Antagonists

Networked: 11 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Chemical Actions and Uses
- Pharmacologic Actions: 160
  - Molecular Mechanisms of Pharmacological Action: 24
    - Neurotransmitter Agents: 13181
      - Serotonin Agents: 404
        Serotonin Antagonists: 596
        Serotonin 5-HT4 Receptor Antagonists: 11
  - Physiological Effects of Drugs: 1
    - Neurotransmitter Agents: 13181
      - Serotonin Agents: 404
        Serotonin Antagonists: 596
        Serotonin 5-HT4 Receptor Antagonists: 11

Experts

1.	Andressen, Kjetil Wessel: 1 article (06/2013)
2.	Brudeli, Bjarne: 1 article (06/2013)
3.	Klaveness, Jo: 1 article (06/2013)
4.	Levy, Finn Olav: 1 article (06/2013)
5.	Moltzau, Lise Román: 1 article (06/2013)
6.	Nguyen, Cam H T: 1 article (06/2013)
7.	Nilsen, Nils Olav: 1 article (06/2013)
8.	Boznańska, Patrycja: 1 article (01/2007)
9.	Moskwa, Anna: 1 article (01/2007)
10.	Baron, A: 1 article (08/2006)

Related Diseases

1.	Pain (Aches) 03/30/1998 - "The objective of this study was to establish the activity profile of SDZ 205-557, a 5-HT4 antagonist, on cutaneous (hotplate) and visceral (writhing) models of pain, after peripheral administration. "
2.	Diarrhea 01/01/2007 - "5-HT4 antagonist--piboserode--is being investigated for a diarrhea predominant IBS." 11/01/1994 - "Pretreatment (5 min before 5-HTP) with GR 113808 or SB 204070, two highly selective 5-HT4 antagonists, significantly inhibited 5-HTP-induced diarrhea with ID50 estimates of 0.31 and 0.003 mg/kg i.p., respectively. "
3.	Cardiac Arrhythmias (Arrythmia) 02/01/2003 - "It also delves into the potential benefits and limitations of 5-HT4 antagonists in the prevention and management of this arrhythmia." 01/01/1998 - "The effect of the 5-HT4 antagonists GR113808A and GR125487D on cocaine-induced cardiac arrhythmia was examined in the rat. "
4.	Irritable Bowel Syndrome (Syndrome, Irritable Bowel) 11/01/1999 - "Our results support a role for the 5-HT4 receptor in the pathophysiology of irritable bowel syndrome and suggest that the selective 5-HT4 antagonist, SB-207266-A, is worthy of further evaluation in this disorder."
5.	Hypovolemia 06/01/2001 - "Effect of the intracerebroventricular administration of GR 113808, a selective 5-HT4 antagonist, on water intake during hyperosmolarity and hypovolemia." 06/01/2001 - "We demonstrate here that acute third ventricle injections of GR 113808, a highly selective 5-HT4 antagonist, decrease water intake induced by a previous salt load while potentiating drinking elicited by hypovolemia induced by previous subcutaneous administration of polyethylene glycol in male Wistar rats (200 +/- 20 g). "

Related Drugs and Biologics

1.	2-methoxy-4-amino-5-chlorobenzoic acid 2-(diethylamino)ethyl ester
2.	GR 113808
3.	Serotonin 5-HT3 Receptor Antagonists
4.	5-HT4 Serotonin Receptors
5.	Ondansetron (Zofran)
6.	Serotonin (5 Hydroxytryptamine)
7.	Scopolamine (Hyoscine)
8.	Salts
9.	Polyethylene Glycols (Polyethylene Glycol)
10.	Cocaine (Cocaine HCl)

Related Therapies and Procedures

1.	Injections