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Serotonin 5-HT1 Receptor Agonists

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Endogenous compounds and drugs that specifically stimulate SEROTONIN 5-HT1 RECEPTORS. Included under this heading are agonists for one or more of the specific 5-HT1 receptor subtypes.

Also Known As:

5-HT1 Agonist; 5-HT1A Agonist; 5-HT1B Agonist; 5-HT1B-D Agonist; 5-HT1D Agonist; Serotonin 5-HT1A Receptor Agonists; Serotonin 5-HT1B Receptor Agonists; Serotonin 5-HT1B-D Agonists; Serotonin 5-HT1D Receptor Agonists; 5 HT1 Agonist; 5 HT1 Agonists; 5 HT1A Agonist; 5 HT1B Agonist; 5 HT1B D Agonist; 5 HT1D Agonist; 5-HT1B-D Agonists, Serotonin; Agonist, 5-HT1; Agonist, 5-HT1A; Agonist, 5-HT1B; Agonist, 5-HT1B-D; Agonist, 5-HT1D; Agonists, 5-HT1; Agonists, Serotonin 5-HT1B-D; Serotonin 5 HT1 Receptor Agonists; Serotonin 5 HT1A Receptor Agonists; Serotonin 5 HT1B D Agonists; Serotonin 5 HT1B Receptor Agonists; Serotonin 5 HT1D Receptor Agonists; 5-HT1 Agonists

Networked: 155 relevant articles (13 outcomes, 23 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Chemical Actions and Uses
- Pharmacologic Actions: 56
  - Molecular Mechanisms of Pharmacological Action: 7
    - Neurotransmitter Agents: 7915
      - Serotonin Agents: 249
        Serotonin Receptor Agonists: 311
        Serotonin 5-HT1 Receptor Agonists: 155
  - Physiological Effects of Drugs: 1
    - Neurotransmitter Agents: 7915
      - Serotonin Agents: 249
        Serotonin Receptor Agonists: 311
        Serotonin 5-HT1 Receptor Agonists: 155

Experts

1.	McCreary, A C: 3 articles (09/2015 - 08/2010)
2.	Sumiyoshi, Tomiki: 3 articles (01/2013 - 03/2006)
3.	Wolf, William A: 3 articles (05/2007 - 07/2003)
4.	Varney, M A: 2 articles (09/2015 - 06/2015)
5.	Cenci, M A: 2 articles (09/2015 - 06/2015)
6.	Newman-Tancredi, A: 2 articles (09/2015 - 06/2015)
7.	Iderberg, H: 2 articles (09/2015 - 06/2015)
8.	Morimoto, Tomoki: 2 articles (04/2015 - 10/2013)
9.	Shimizu, Saki: 2 articles (04/2015 - 10/2013)
10.	Sobue, Akira: 2 articles (04/2015 - 10/2013)

Related Diseases

1.	Migraine Disorders (Migraine) 06/01/1993 - "Further studies are cited to support two possible mechanisms of action for the efficacy of 5-HT1 agonists in treating migraine. " 09/01/2001 - "Safety and efficacy of PNU-142633, a selective 5-HT1D agonist, in patients with acute migraine." 01/01/1996 - "311C90, a novel 5-HT1D agonist drug, which is also highly effective in the acute treatment of migraine, acts not only at these sites, but, additionally within the brainstem, inhibiting trigemino-vascular activation centrally as well as peripherally. " 01/01/1996 - "The 5-HT1D agonist sumatriptan, which is highly effective in the acute treatment of migraine, inhibits trigemino-vascular activation in animals, although its actions are normally limited to peripheral components of the trigemino-vascular system. " 04/01/1997 - "The efficacy of BMS 180048, a 5-HT1 agonist in the acute treatment of a migraine headache, was evaluated in 216 patients. "
2.	Cerebellar Ataxia (Dysmetria) 01/01/2005 - "Treatment of cerebellar ataxia with 5-HT1A agonist." 01/01/2004 - "In a double-blind randomized study, buspirone, a 5-HT1A agonist was active in cerebellar ataxia, but the effect is partial and not major. " 01/01/1997 - "To test further the serotonergic hypothesis of cerebellar ataxia, we administered buspirone, a 5-HT1A agonist usable in human medicine, in a randomized double blind drug placebo trial for 4 months. " 01/01/1997 - "Buspirone, a serotonergic 5-HT1A agonist, is active in cerebellar ataxia. " 01/01/2005 - "We recently reported preliminary evidence that tandospirone citrate (tandospirone), a 5-HT1A agonist, improved cerebellar ataxia in patients with Machado-Joseph disease (MJD). "
3.	Dyspepsia (Indigestion) 03/01/2002 - "5-HT1 agonists improve impaired gastric accommodation and symptoms in patients with functional dyspepsia. " 01/01/2002 - "5-HT1 agonists may play a role in treating functional dyspepsia, partly by improving impaired gastric accommodation to a meal. " 06/01/2009 - "A placebo-controlled trial of the 5-HT1A agonist R-137696 on symptoms, visceral hypersensitivity and on impaired accommodation in functional dyspepsia." 11/01/2009 - "Efficacy of the 5-HT1A agonist tandospirone citrate in improving symptoms of patients with functional dyspepsia: a randomized controlled trial." 02/01/2013 - "The effects of antidepressants on the gastrointestinal tract may contribute to their potential efficacy in functional dyspepsia and irritable bowel syndrome; buspirone, a prototype 5-HT1A agonist, enhances gastric accommodation and reduces postprandial symptoms in response to a challenge meal. "
4.	Anxiety Disorders (Anxiety Disorder) 06/01/2006 - "We report the discovery of a novel, potent, and selective amidosulfonamide nonazapirone 5-HT1A agonist for the treatment of anxiety and depression, which is now in Phase III clinical trials for generalized anxiety disorder (GAD). " 09/01/2005 - "To examine the efficacy of buspirone, a 5-HT1A agonist, for migraine combined with anxiety disorder. " 01/01/2005 - "Although the picture is far from complete yet--partly due to the large number of serotonin (5-HT) receptors and the often-disparate effects of receptor agonists and antagonists in animal models of anxiety--SSRIs and the 5-HT1A agonist buspirone have now earned their place in the treatment of anxiety disorders. "
5.	Muscle Rigidity 12/01/2003 - "Provided these results can be extrapolated to humans, the efficacy of EMD 128130 in relieving the haloperidol-induced muscle rigidity supports the concept that novel antipsychotics with 5-HT1A agonist and dopamine D2 antagonist activities should have a favourable extrapyramidal side-effect profile." 12/01/2003 - "The aim of the present study was to find out whether (+/-)-8-hydroxy-2(di-n-propylamino)tetralin (8-OH-DPAT), a prototypical 5-HT1A agonist, and (R)-(-)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane HCl (EMD 128130), a compound with serotonin 5-HT1A-agonist and dopamine D2-like antagonist properties, are able to attenuate the haloperidol-induced (1 mg/kg) muscle rigidity in rats. "

Related Drugs and Biologics

1.	tandospirone
2.	Buspirone (Buspar)
3.	Citric Acid (Citrate)
4.	Dopamine (Intropin)
5.	Haloperidol (Haldol)
6.	Antipsychotic Agents (Antipsychotics)
7.	Sumatriptan (Imigran)
8.	zolmitriptan (Zomig)
9.	BMS 180048
10.	8-Hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT)

Related Therapies and Procedures

1.	Injections
2.	Intravenous Injections
3.	Analgesia
4.	Oral Administration