Levoleucovorin

A folate analog consisting of the pharmacologically active isomer of LEUCOVORIN.

Also Known As:

(6S)-leucovorin; 6-S-leucovorin; 6S-leucovorin; Fusilev; Leucovorin, (S)-Isomer; Leucovorin, Calcium (1:1) Salt, (S)-Isomer; Leucovorin, Monopotassium Salt, (S)-Isomer; Leucovorin, Monosodium Salt, (S)-Isomer; S-leucovorin; levo-leucovorin; 6 S leucovorin; 6S leucovorin; S leucovorin; levo leucovorin

Networked: 43 relevant articles (1 outcomes, 18 trials/studies)

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Pteridines: 147
      - Pterins: 160
        Folic Acid: 19425
        Tetrahydrofolates: 8
        Formyltetrahydrofolates
        Leucovorin: 5743
        Levoleucovorin: 43
        ELF protocol
        PELF protocol 2
        PFLI-alpha protocol

Experts

1.	Komatsu, Yoshito: 2 articles (08/2012 - 01/2010)
2.	Barni, S: 2 articles (05/2011 - 04/2004)
3.	Beretta, G D: 2 articles (05/2011 - 04/2004)
4.	Labianca, R: 2 articles (05/2011 - 04/2004)
5.	Sobrero, A: 2 articles (05/2011 - 01/2005)
6.	Zaniboni, A: 2 articles (05/2011 - 04/2004)
7.	Comella, Pasquale: 2 articles (02/2009 - 09/2005)
8.	Farris, Antonio: 2 articles (02/2009 - 09/2005)
9.	Filippelli, Gianfranco: 2 articles (02/2009 - 09/2005)
10.	Maiorino, Luigi: 2 articles (02/2009 - 09/2005)

Related Diseases

1.	Colorectal Neoplasms (Colorectal Cancer) 11/15/1996 - "A total of 130 previously untreated patients with locally advanced or metastatic colorectal carcinoma were randomized to receive oral levo-leucovorin (1-leucovorin) 25 mg/dose followed by oral 5-dFUR 750 mg/m2 twice daily for 4 days every 12 days (arm A) or i.v. 1-leucovorin 25 mg/dose followed by i.v. 5-dFUR 3000 mg/m2 for 5 days every 21 days (arm B). " 04/03/1996 - "Role of fluoropyrimidine Schedule and (6R,S)leucovorin dose in a preclinical animal model of colorectal carcinoma." 10/01/1995 - "One hundred eight patients with histologically proven colorectal cancer received orally administered levo-leucovorin 25 mg followed 2 hours later by dFUR 1,200 mg/m2 on days 1 to 5, with the cycle being repeated every 10 days. " 01/01/1993 - "These observations led us to test the clinical activity of a standard regimen of CI FU (300 mg/m2 per day) in a cohort of 15 patients with advanced measurable colorectal cancer who were in progression after having failed to respond to bolus treatment with FU alone (3 patients) or FU combined with high-dose 6-S-leucovorin (LV) (12 patients). " 02/01/1997 - "High-versus low-dose levo-leucovorin as a modulator of 5-fluorouracil in advanced colorectal cancer: a 'GISCAD' phase III study. "
2.	Neoplasms (Cancer) 06/20/2023 - "Further, a dose dependent inhibition of cancer cell migration was noted along with apoptosis induction in these cells with levoleucovorin treatment.Communicated" 10/01/2012 - "Levoleucovorin has been studied in other cancers. " 10/01/2009 - "This is an extensive literature review of levoleucovorin use in patients with gastrointestinal tract malignancies. " 10/01/2012 - "To comprehensively review the literature regarding the efficacy, safety, and costs associated with the use of levoleucovorin in cancer treatment and to assess whether levoleucovorin would be a reasonable alternative to the use of racemic leucovorin. " 10/01/2012 - "Levoleucovorin as replacement for leucovorin in cancer treatment."
3.	Stomach Neoplasms (Stomach Cancer) 01/01/1994 - "A total of 23 advanced gastric cancer patients older than 65 years received 500 mg/m2 5-fluorouracil i.v. on days 2-4, 120 mg/m2 vepesid i.v. on days 2-4, 150 mg/m2 6S-leucovorin on days 2-4, and 5 MU/m2 interferon alpha-2b on days 1-5, with cycles being repeated every 3 weeks. " 10/31/1993 - "Starting 14 to 21 days after potentially curative resection of primary gastric cancers, 22 patients were given intraperitoneal cisplatin, 60 mg/m2; 5-fluorouracil, 1000 mg/m2; 6S-leucovorin, 250 mg/m2; interferon alpha 2b, 10 MU/m2; every other week for six times. " 10/31/1993 - "A pilot clinical trial of postoperative adjuvant intraperitoneal cisplatin, 5-fluorouracil, 6S-leucovorin and interferon alpha 2b in patients with resected gastric cancer." 09/01/1993 - "Thirty-four advanced gastric cancer patients received, every week for nine weeks, 5-fluorouracil 500 mg/m2 iv; epi-doxorubicin 35 Mg/M2 iv; cisplatin 40 Mg/M2 iv; 6S-leucovorin 250 mg/M2 in 4 hour infusion. " 10/31/1993 - "Intraperitoneal cisplatin, 5-fluorouracil, 6S-leucovorin and interferon is a tolerable therapy in the postoperative setting for patients with resected gastric cancer. "
4.	Breast Neoplasms (Breast Cancer) 06/20/2023 - "Further validation of levoleucovorin against LOXL2 activity is warranted toward repurposing levoleucovorin as a therapeutic agent for treating breast cancer patients. " 06/20/2023 - "Levoleucovorin inhibits LOXL2 (lysyl oxidase like-2) to control breast cancer proliferation: a repurposing approach." 09/15/1998 - "Oral doxifluridine plus levoleucovorin in elderly patients with advanced breast cancer." 11/01/1993 - "The influence of the addition of [6S]leucovorin (LV) to 5-fluorouracil (5-FU) preoperative chemotherapy was examined in patients with surgically resectable breast cancer who had had no prior treatment. " 01/01/1996 - "Phase II study of mitoxantrone, 5-fluorouracil, and levo-leucovorin (MLF) in elderly advanced breast cancer patients."
5.	Colonic Neoplasms (Colon Cancer) 01/01/2015 - "The aim was to compare the concentration of folate metabolites in tumor, mucosa, and plasma of patients with colon cancer after administration of Modufolin® or Isovorin® (levo-leucovorin). " 01/17/2005 - "The aim of the study was to determine whether modulation of 5-fluorouracil (FU) by methotrexate (MTX) improves survival compared to FU+6-s-leucovorin (LV) following potentially curative resection of stage II and III colon cancer. "

Related Drugs and Biologics

1.	Fluorouracil (Carac)
2.	Antineoplastic Agents (Antineoplastics)
3.	Irinotecan (Camptosar)
4.	Cisplatin (Platino)
5.	Glutathione (Reduced Glutathione)
6.	doxifluridine
7.	Methotrexate (Mexate)
8.	Filgrastim (Neupogen)
9.	Leucovorin (Folinic Acid)
10.	Doxorubicin (Adriamycin)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics
3.	Salvage Therapy
4.	Radiotherapy
5.	Treatment Delay