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Out-of-Hospital Cardiac Arrest

Subscribe to New Research on Out-of-Hospital Cardiac Arrest

Occurrence of heart arrest in an individual when there is no immediate access to medical personnel or equipment.

Also Known As:

Out-of-Hospital Heart Arrest; Cardiac Arrest, Out-of-Hospital; Cardiac Arrests, Out-of-Hospital; Heart Arrest, Out-of-Hospital; Heart Arrests, Out-of-Hospital; Out of Hospital Cardiac Arrest; Out of Hospital Heart Arrest; Out-of-Hospital Cardiac Arrests; Out-of-Hospital Heart Arrests

Networked: 1339 relevant articles (84 outcomes, 275 trials/studies)

Relationship Network

Disease Context: Research Results

Cardiovascular Diseases: 37259
- Heart Diseases: 18762
  - Heart Arrest: 11039
    - Out-of-Hospital Cardiac Arrest: 1339

Related Diseases

1.	Heart Arrest (Cardiac Arrest)
2.	Ventricular Fibrillation
3.	Hypothermia
4.	Shock
5.	Ventricular Tachycardia

Experts

1.	Nichol, Graham: 30 articles (12/2015 - 02/2003)
2.	Callaway, Clifton W: 28 articles (12/2015 - 02/2002)
3.	Morrison, Laurie J: 26 articles (12/2015 - 11/2005)
4.	Rea, Thomas D: 24 articles (12/2015 - 04/2003)
5.	Aufderheide, Tom P: 24 articles (12/2015 - 09/2004)
6.	Herlitz, J: 23 articles (06/2013 - 03/2000)
7.	Iwami, Taku: 22 articles (11/2015 - 05/2006)
8.	Berg, Robert A: 22 articles (11/2015 - 03/2005)
9.	Bobrow, Bentley J: 22 articles (11/2015 - 10/2007)
10.	Herlitz, Johan: 22 articles (10/2015 - 07/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Out-of-Hospital Cardiac Arrest:

1.	Epinephrine (Adrenaline)FDA LinkGeneric 01/01/2014 - "Is adrenaline safe and effective as a treatment for out of hospital cardiac arrest?" 07/01/2010 - "One possible explanation for the lack of epinephrine's demonstrated efficacy in human trials of out-of-hospital cardiac arrest is the delay in its administration. " 12/09/2014 - "This study sought to investigate the relationship between pre-hospital use of epinephrine and functional survival among patients with out-of-hospital cardiac arrest (OHCA) who achieved successful ROSC. " 03/01/2014 - "Jacobs IG, Finn JC, Jelinek GA, et al. Effect of adrenaline on survival in out-of-hospital cardiac arrest: a randomised double-blind placebo-controlled trial. " 01/01/2014 - "The aim of this study was to conduct a systematic review and meta-analysis for determining the effects of prehospital adrenaline administration on return of spontaneous circulation, hospital admission, survival to discharge and discharge with cerebral performance category 1 or 2 in out-of-hospital cardiac arrest patients. "
2.	OxygenIBA 11/01/2015 - "Regional cerebral oxygen saturation monitoring for predicting interventional outcomes in patients following out-of-hospital cardiac arrest of presumed cardiac cause: A prospective, observational, multicentre study." 11/01/2015 - "Characteristics of regional cerebral oxygen saturation levels in patients with out-of-hospital cardiac arrest with or without return of spontaneous circulation: A prospective observational multicentre study." 06/01/2014 - "Noninvasive regional cerebral oxygen saturation for neurological prognostication of patients with out-of-hospital cardiac arrest: a prospective multicenter observational study." 01/01/2013 - "Continuous passive oxygen insufflation for out-of-hospital cardiac arrest: a systemic review of clinical studies." 04/01/2004 - "In the present study seven adult, non-traumatic, out-of-hospital cardiac arrest patients were intubated and mechanically ventilated at 12 min(-1) with 100% oxygen and a tidal volume of 700 ml (10 +/- 2 ml kg(-1)). "
3.	Amiodarone (Amiodarona)FDA LinkGeneric 10/01/1998 - "The ARREST trial, a randomized trial comparing IV amiodarone to placebo, found a significant improvement in the proportion of patients surviving to the emergency department following out-of-hospital cardiac arrest in amiodarone-treated patients. " 05/01/2004 - "The present study suggests that amiodarone can be administered undiluted without unmanageable haemodynamical side-effects in the treatment of out-of-hospital cardiac arrest. " 09/16/1999 - "We conducted a randomized, double-blind, placebo-controlled study of intravenous amiodarone in patients with out-of-hospital cardiac arrest. " 04/01/2010 - "In patients with ACS and ventricular arrhythmias (VTA) amiodarone is the drug of choice; this drug is highly effective even in patients with defibrillation-resistant out-of-hospital cardiac arrest. " 05/01/2004 - "Amiodarone has been associated with side-effects and difficulty of administration, due to recommended dilution, rendering it suboptimal for out-of-hospital cardiac arrest (CA) management. "
4.	Vasopressins (Vasopressin)IBA 01/01/2006 - "We conclude that pre-hospital access to defibrillators and the use of vasopressin in the management of asystole hold promise for improving survival for patients with out-of-hospital cardiac arrest." 04/01/2002 - "Currently, a large trial comprising patients who experience out-of-hospital cardiac arrest and who are treated with vasopressin vs. epinephrine is ongoing in Germany, Austria, and Switzerland. " 08/15/2001 - "Currently, a large trial of out-of-hospital cardiac arrest patients being treated with vasopressin vs. epinephrine is ongoing in Germany, Austria and Switzerland. " 06/01/2001 - "Currently, a large trial of out-of-hospital cardiac arrest patients being treated with vasopressin versus epinephrine is ongoing in Germany, Austria, and Switzerland. " 11/15/2006 - "Usefulness of vasopressin administered with epinephrine during out-of-hospital cardiac arrest."
5.	Lidocaine (Xylocaine)FDA LinkGeneric 01/01/1997 - "To describe the proportion of patients with witnessed out-of-hospital cardiac arrest found in ventricular fibrillation who survived and were discharged from hospital in relation to whether they were treated with lidocaine prior to hospital admission. " 03/21/2002 - "We performed a randomized trial comparing intravenous lidocaine with intravenous amiodarone as an adjunct to defibrillation in victims of out-of-hospital cardiac arrest. " 10/01/2014 - "Regarding manuscript: "resuscitation outcomes consortium-amiodarone, lidocaine, or placebo study: rationale and methodology behind out-of-hospital cardiac arrest antiarrhythmic drug trial"." 10/01/2014 - "Letter to the editor regarding manuscript "resuscitation outcomes consortium-amiodarone, lidocaine or placebo: rationale and methodology behind out-of-hospital cardiac arrest antiarrhythmic drug trial"." 05/01/2014 - "Resuscitation Outcomes Consortium-Amiodarone, Lidocaine or Placebo Study (ROC-ALPS): Rationale and methodology behind an out-of-hospital cardiac arrest antiarrhythmic drug trial."
6.	Amsacrine (AMSA)IBA 02/03/2015 - "This study sought to validate the ability of amplitude spectrum area (AMSA) to predict defibrillation success and long-term survival in a large population of out-of-hospital cardiac arrests. " 09/30/2014 - "Previous investigations of out-of-hospital cardiac arrest (OHCA) have shown that the waveform characteristic amplitude spectral area (AMSA) can predict successful defibrillation and return of spontaneous circulation (ROSC) but has not been studied previously for survival. " 12/01/2013 - "The capability of amplitude spectrum area (AMSA) to predict the success of defibrillation (DF) was retrospectively evaluated in a large database of out-of-hospital cardiac arrests. " 07/01/2015 - "In out-of-hospital cardiac arrest (OHCA) with ventricular fibrillation (VF) the frequency-based waveform characteristic, amplitude-spectral area (AMSA) is associated with hospital discharge and good neurological outcome, yet AMSA is also known to increase in response to chest compressions (CC). " 01/01/2008 - "In the present study we sought to examine the efficacy of an electrocardiographic parameter, 'amplitude spectrum area' (AMSA), to predict the likelihood that any one electrical shock would restore a perfusing rhythm during cardiopulmonary resuscitation in human victims of out-of-hospital cardiac arrest. "
7.	cytidylyl-(3'-5')-cytidine (CpC)IBA 08/01/2009 - "Thirty percent of 681 patients showed a significant change in functional outcome and mortality between one month and six months after out-of hospital cardiac arrest, 12% improved in CPC, 1% deteriorated, 17% died. " 09/01/2014 - "Studies on out-of-hospital cardiac arrest (OHCA) use overall performance category (OPC)/cerebral performance category (CPC) as outcome. " 08/01/2009 - "In this cohort study we posed the hypothesis that there are no significant changes in Cerebral Performance Categories (CPC) between one month and six months after out-of hospital cardiac arrest. " 12/01/1996 - "We compared CPC scores with the results of prospective standardized testing after discharge in survivors of out-of-hospital cardiac arrest. " 01/01/2014 - "Among patients surviving at 6 months, 99% in the mechanical CPR group and 94% in the manual CPR group had CPC scores of 1 or 2. Among adults with out-of-hospital cardiac arrest, there was no significant difference in 4-hour survival between patients treated with the mechanical CPR algorithm or those treated with guideline-adherent manual CPR. "
8.	tenecteplase FDA Link 12/18/2008 - "When tenecteplase was used without adjunctive antithrombotic therapy during advanced life support for out-of-hospital cardiac arrest, we did not detect an improvement in outcome, in comparison with placebo. " 12/18/2008 - "In a double-blind, multicenter trial, we randomly assigned adult patients with witnessed out-of-hospital cardiac arrest to receive tenecteplase or placebo during cardiopulmonary resuscitation. " 05/01/2005 - "International multicentre trial protocol to assess the efficacy and safety of tenecteplase during cardiopulmonary resuscitation in patients with out-of-hospital cardiac arrest: the Thrombolysis in Cardiac Arrest (TROICA) Study." 02/01/2010 - "Changes in amplitude spectrum area (AMSA) and mean fibrillation (MF) in patients with sustained VF were analysed after administration of rt-PA variant tenecteplase in out-of-hospital cardiac arrest (OHCA) during cardiopulmonary resuscitation (CPR). "
9.	MS 551IBA 11/01/2010 - "Report from J-PULSE multicenter registry of patients with shock-resistant out-of-hospital cardiac arrest treated with nifekalant hydrochloride." 03/01/2003 - "[Efficacy of Nifekalant hydrochloride for life-threatening ventricular tachyarrhythmias in patients with resistance to lidocaine: a study of patients with out-of-hospital cardiac arrest]." 04/01/2006 - "As compared with lidocaine, nifekalant may improve short-term survival in patients with out-of-hospital cardiac arrest due to shock-refractory ventricular fibrillation."
10.	IceIBA 02/01/2012 - "ED staff need to be aware that the use of ice-cold fluids is an inexpensive, readily available and easy to perform method of inducing MTH in patients who suffer an out-of hospital cardiac arrest with a ventricular rhythm. " 08/17/2010 - "In adults who have been resuscitated from out-of-hospital cardiac arrest with an initial cardiac rhythm of ventricular fibrillation, paramedic cooling with a rapid infusion of large-volume, ice-cold intravenous fluid decreased core temperature at hospital arrival but was not shown to improve outcome at hospital discharge compared with cooling commenced in the hospital." 01/01/2011 - "All in-hospital cardiac arrest (IHCA) and out-of-hospital cardiac arrest (OHCA) patients admitted to an intensive care unit meeting inclusion criteria were cooled using a combination modality of rapid, cold saline infusion (CSI), evaporative surface cooling, and ice water gastric lavage. " 05/01/2011 - "Intravenous (IV) infusion of ice cold saline is an effective method to initiate induction of mild therapeutic hypothermia (MTH) following resuscitation from out-of-hospital cardiac arrest (OOHCA). " 01/01/2003 - "Induced hypothermia using large volume, ice-cold intravenous fluid in comatose survivors of out-of-hospital cardiac arrest: a preliminary report."

Therapies and Procedures

1.	Cardiopulmonary Resuscitation (CPR) 01/01/2009 - "Training all persons across an entire community in CPR may have a logarithmic improvement in survival rates for out-of-hospital cardiac arrest because bystanders, usually family members, are more likely to know CPR and can perform it immediately, when it is physiologically most effective. " 09/01/2006 - "Witnessed collapse and bystander CPR are the variables most frequently associated with good outcome from out-of-hospital cardiac arrest (OOHCA). " 11/06/2010 - "In out-of-hospital cardiac arrest, dispatcher-assisted chest-compression-only bystander CPR might be superior to standard bystander CPR (chest compression plus rescue ventilation), but trial findings have not shown significantly improved outcomes. " 01/01/2014 - "The presence of a physician seems to be beneficial for pre-hospital cardiopulmonary resuscitation (CPR) of patients with out-of-hospital cardiac arrest. " 05/01/2013 - "High-quality CPR is associated with improved outcomes from out-of-hospital cardiac arrest (OHCA). "
2.	Resuscitation 04/01/2002 - "The quality of life in long-term survivors of out-of-hospital cardiac arrest may be a good outcome measure after resuscitation. " 12/01/1999 - "The involvement of general practitioners in community based resuscitation of out-of-hospital cardiac arrest has been found to be effective in improving survival rates. " 06/01/2008 - "Cardiocerebral resuscitation (CCR) is a new approach to patients with out-of-hospital cardiac arrest that has been shown to improve rates of neurologically intact survival by 250%-300% over the approach advocated by the 2000 American Heart Association guidelines. " 08/01/2013 - "This study aimed to determine whether active post-resuscitation care (APRC) was associated with improved out-of-hospital cardiac arrest (OHCA) outcomes on a nationwide level. " 08/14/2001 - "The aim of the present study was to determine the feasibility, safety, and efficacy of the Lifestick compared with conventional resuscitation in patients with sudden nontraumatic out-of-hospital cardiac arrest. "
3.	Defibrillators (Defibrillator) 01/01/2007 - "Placement of automated external defibrillators in public facilities is a cost-effective treatment for out-of-hospital cardiac arrests. " 10/01/2015 - "Targeted automated external defibrillator (AED) programs have improved survival rates among patients who have an out-of-hospital cardiac arrest (OHCA) in US airports, as well as European and Japanese railways. " 11/18/2014 - "Improved survival after out-of-hospital cardiac arrest and use of automated external defibrillators." 10/01/2012 - "In mass gathering sports events, the availability of an onsite emergency response plan including early access to automated external defibrillators by trained lay rescuers has been shown to improve survival among spectators and staff with out-of-hospital cardiac arrest and to reduce subsequent neurological deficit. " 04/01/1986 - "Efficacy of an automated external defibrillator in the management of out-of-hospital cardiac arrest: validation of the diagnostic algorithm and initial clinical experience in a rural environment."
4.	Induced Hypothermia 10/01/2010 - "Improved out-of-hospital cardiac arrest survival after the sequential implementation of 2005 AHA guidelines for compressions, ventilations, and induced hypothermia: the Wake County experience." 01/01/2007 - "Efficacy of and tolerance to mild induced hypothermia after out-of-hospital cardiac arrest using an endovascular cooling system." 02/09/2008 - "In 2002, two prospective randomised multicentre studies demonstrated that induced mild hypothermia can increase the chance of good neurologic recovery after out-of-hospital cardiac arrest by at least 40%. " 01/01/2003 - "Recent studies have shown that induced hypothermia for twelve to twenty four hours improves outcome in patients who are resuscitated from out-of-hospital cardiac arrest. " 08/01/2015 - "The reliability of some methods of neurological prognostication after out-of-hospital cardiac arrest has been questioned since the introduction of induced hypothermia. "
5.	Decompression 04/01/2005 - "A 62-year-old man suffered out-of-hospital cardiac arrest and was treated with mechanical compression-decompression during transport to the hospital. " 03/01/2005 - "Incomplete chest wall decompression was observed at some time during resuscitative efforts in 6 (46%) of 13 consecutive adult out-of-hospital cardiac arrests. " 06/01/2004 - "The use of an impedance valve in patients receiving active compression-decompression cardiopulmonary resuscitation for out-of-hospital cardiac arrest significantly improved 24 h survival rates." 04/01/2015 - "Active compression-decompression resuscitation and impedance threshold device for out-of-hospital cardiac arrest: a systematic review and metaanalysis of randomized controlled trials." 01/22/2011 - "Standard cardiopulmonary resuscitation versus active compression-decompression cardiopulmonary resuscitation with augmentation of negative intrathoracic pressure for out-of-hospital cardiac arrest: a randomised trial."