Nanodiamonds

Diamond nanoparticles that exhibit unique biological, thermal, mechanical, and optoelectronic properties. They have important NANOMEDICINE applications including DRUG DELIVERY SYSTEMS; DIAGNOSTIC IMAGING; protein separation; and BIOSENSING TECHNIQUES.

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Networked: 204 relevant articles (15 outcomes, 29 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ho, Dean: 16 articles (11/2018 - 11/2007)
2.	Komatsu, Naoki: 10 articles (09/2021 - 11/2011)
3.	Chow, Edward Kai-Hua: 9 articles (10/2021 - 02/2014)
4.	Zhao, Li: 9 articles (09/2021 - 07/2014)
5.	Chang, Huan-Cheng: 8 articles (01/2017 - 10/2009)
6.	Chen, Xiao: 7 articles (09/2021 - 07/2014)
7.	Xu, Yong-Hong: 7 articles (09/2021 - 07/2014)
8.	Treussart, François: 7 articles (05/2021 - 11/2011)
9.	Choi, Sung-Wook: 6 articles (09/2021 - 10/2015)
10.	Li, Ke: 6 articles (09/2021 - 10/2018)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2017 - "Nanodiamonds and nanoparticles as tumor cell radiosensitizers-promising results but an obscure mechanism of action." 01/01/2015 - "Nanodiamonds as a novel platform hold great promise for targeting cancer cells and in-vivo cell imaging. " 09/12/2023 - "In conclusion, this study provides a rationale for the development of new therapeutic strategies based on use of miR-34a delivered by nanodiamonds to improve the clinical treatment of neoplasms." 07/15/2021 - "HeLa cells are interesting to study with these nanodiamonds since they are a model cell system that is widely used to study cancer-related diseases. " 10/21/2009 - "The objective of this study is to evaluate the biocompatibility and the mechanism of the cellular uptake of fluorescent nanodiamonds (FNDs) in cancer cells (HeLa) and pre-adipocytes (3T3-L1). "
2.	Breast Neoplasms (Breast Cancer) 07/05/2018 - "We show for the first time that oxidized nanodiamonds possess improved biocompatibility compared to graphitic nanodiamonds in breast cancer cell lines, with graphitic nanodiamonds inducing higher levels of oxidative stress despite lower uptake." 03/24/2015 - "The work reported here applied a powerful phenotypically driven platform, termed feedback system control (FSC), that systematically and rapidly converges upon a combination consisting of three nanodiamond-modified drugs and one unmodified drug that is simultaneously optimized for efficacy against multiple breast cancer cell lines and safety against multiple control cell lines. " 09/12/2023 - "Moreover, we evaluated nanodiamond cytotoxicity on two breast cancer cell models and confirmed their excellent biocompatibility. " 09/12/2023 - "Fluorescent nanodiamonds as innovative delivery systems for MiR-34a replacement in breast cancer." 07/05/2018 - "Graphitic and oxidised high pressure high temperature (HPHT) nanodiamonds induce differential biological responses in breast cancer cell lines."
3.	Triple Negative Breast Neoplasms 08/21/2021 - "A multifunctional nanodiamond-based nanoplatform for the enhanced mild-temperature photothermal/chemo combination therapy of triple negative breast cancer via an autophagy regulation strategy." 05/18/2021 - "Multicomponent-assembled nanodiamond hybrids for targeted and imaging guided triple-negative breast cancer therapy via a ternary collaborative strategy." 04/11/2018 - "Nanodiamond-based layer-by-layer nanohybrids mediate targeted delivery of miR-34a for triple negative breast cancer therapy." 07/12/2013 - "Self-assembled nanodiamond-lipid hybrid particles (NDLPs) harness the potent interaction between the nanodiamond (ND)-surface and small molecules, while providing a mechanism for cell-targeted imaging and therapy of triple negative breast cancers. " 01/01/2019 - "Targeting EGFR of triple-negative breast cancer enhances the therapeutic efficacy of paclitaxel- and cetuximab-conjugated nanodiamond nanocomposite."
4.	Neoplasm Metastasis (Metastasis) 11/01/2023 - "Carboxyl nanodiamonds inhibit melanoma tumor metastases by blocking cellular motility and invasiveness." 11/21/2019 - "Development of multi-drug loaded PEGylated nanodiamonds to inhibit tumor growth and metastasis in genetically engineered mouse models of pancreatic cancer." 12/01/2013 - "Nanodiamonds-mediated doxorubicin nuclear delivery to inhibit lung metastasis of breast cancer." 01/01/2018 - "In this study, we investigated the use of nanodiamonds to develop a stimuli-responsive metastasis detection complex that utilizes matrix metalloproteinase 9 (MMP9) as a metastasis biomarker, as MMP9 increased expression has been shown to be indicative of metastasis. " 05/01/2014 - "The use of lipid-coated nanodiamond to improve bioavailability and efficacy of sorafenib in resisting metastasis of gastric cancer."
5.	Ewing Sarcoma (Sarcoma, Ewing) 01/01/2012 - "Influence of the internalization pathway on the efficacy of siRNA delivery by cationic fluorescent nanodiamonds in the Ewing sarcoma cell model." 03/01/2015 - "Plasma hydrogenated cationic detonation nanodiamonds efficiently deliver to human cells in culture functional siRNA targeting the Ewing sarcoma junction oncogene." 11/04/2011 - "Nanodiamond as a vector for siRNA delivery to Ewing sarcoma cells." 03/19/2020 - "Delivery of siRNA to Ewing Sarcoma Tumor Xenografted on Mice, Using Hydrogenated Detonation Nanodiamonds: Treatment Efficacy and Tissue Distribution." 03/19/2020 - "In this report, we studied the capacity of cationic hydrogenated detonation nanodiamonds to carry active small interfering RNA (siRNA) in a mice model of Ewing sarcoma, a bone cancer of young adults due in the vast majority to the EWS-FLI1 junction oncogene. "

Related Drugs and Biologics

1.	diazonaphthalenedisulfonic acid (NDS)
2.	Doxorubicin (Adriamycin)
3.	Small Interfering RNA (siRNA)
4.	Carbon
5.	Carbon Nanotubes (Carbon Nanotube)
6.	Paclitaxel (Taxol)
7.	Graphite
8.	Lipids
9.	Cetuximab (Erbitux)
10.	Quercetin

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Quantum Dots (Quantum Dot)
4.	Precision Medicine
5.	Cell- and Tissue-Based Therapy (Cell Therapy)