Decorin

A small leucine-rich proteoglycan that interacts with FIBRILLAR COLLAGENS and modifies the EXTRACELLULAR MATRIX structure of CONNECTIVE TISSUE. Decorin has also been shown to play additional roles in the regulation of cellular responses to GROWTH FACTORS. The protein contains a single glycosaminoglycan chain and is similar in structure to BIGLYCAN.

Also Known As:

Networked: 629 relevant articles (24 outcomes, 103 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Iozzo, Renato V: 55 articles (12/2015 - 03/2002)
2.	Schaefer, Liliana: 16 articles (10/2015 - 03/2002)
3.	Owens, Rick T: 16 articles (04/2014 - 02/2005)
4.	Neill, Thomas: 12 articles (12/2015 - 12/2010)
5.	Seidler, Daniela G: 10 articles (05/2013 - 08/2004)
6.	Wight, Thomas N: 7 articles (04/2015 - 10/2002)
7.	Buraschi, Simone: 7 articles (04/2014 - 12/2010)
8.	Tredget, Edward E: 6 articles (08/2015 - 05/2011)
9.	Iozzo, R V: 6 articles (03/2015 - 10/2000)
10.	Postma, Dirkje S: 6 articles (10/2013 - 03/2005)

Related Diseases

1.	Fibrosis (Cirrhosis) 11/01/2011 - "The best results were obtained when surgery was used in conjunction with decorin that reduced both the PVR score and fibrosis development significantly (p < 0.05). " 06/01/2011 - "Tissue-targeted AAV5-mediated decorin gene therapy is effective and safe for treating corneal fibrosis in vivo." 09/01/2003 - "However, when we blocked the fibrosis process with decorin, an antifibrosis agent, we improved the muscle healing. " 01/01/2014 - "The aim of this study was to investigate the anti-fibrosis effect and the possible underlying mechanisms of decorin. " 06/01/2011 - "This study tested a hypothesis that tissue-selective targeted decorin gene therapy delivered to the stroma with adeno-associated virus serotype 5 (AAV5) inhibits corneal fibrosis in vivo without significant side effects. "
2.	Neoplasms (Cancer) 05/01/2013 - "In this article, we summarize recent studies of decorin in cancer and discuss decorin's therapeutic and prognostic value." 05/01/2013 - "More recent studies show that decorin plays important roles during tumor development and progression and is a potential cancer therapeutic agent. " 03/01/2011 - "Studies have linked decorin dysregulation to delayed tissue healing in patients with various diseases including cancer. " 07/01/2008 - "Thus, decorin is likely to possess a suppressive effect on human tumor angiogenesis in vivo, as previously described by studies using different experimental models. " 06/01/2008 - "Decorin is a major extracellular matrix protein which has become the focus of various cancer studies. "
3.	Cicatrix (Scar) 10/01/2013 - "This study assessed the potential of highly purified (Stro-1(+)) human mesenchymal precursor cells (hMPCs) in combination with the anti-scarring protein decorin to repair the injured spinal cord (SC). " 08/01/2015 - "Reduced decorin synthesis is associated with dermal scarring, and increased decorin expression appears to reduce scar tissue formation. " 09/15/2014 - "Here, we discuss the potential of using Decorin to antagonise scarring in the central nervous system. " 08/25/2013 - "Recombinant decorin suppresses inflammatory reactions, inhibits glial scar formation, and promotes axonal growth. " 09/01/2012 - "Deep dermal fibroblasts refractory to migration and decorin-induced apoptosis contribute to hypertrophic scarring."
4.	Neoplasm Metastasis (Metastasis) 01/01/2012 - "This study indicates that high expression of Decorin is associated with lymph node metastasis (p<0.001), higher number of positive lymph nodes (p<0.0001) and worse overall survival (p = 0.01). " 05/01/2015 - "We also showed that overexpression of decorin could inhibit NSCLC cell lines proliferation and metastasis. " 05/01/2015 - "Via ectopic expression analyses and Western blot, the roles of decorin in proliferation, metastasis, and the underline mechanism for decorin expression were further explored. " 07/01/2013 - "Down-regulation of decorin expression and the presence of lymph node metastasis were adverse factor independently affecting overall survival in OSCC." 07/01/2013 - "Lymph node metastasis and reduced decorin expression independently correlated with overall survival in OSCC. "
5.	Breast Neoplasms (Breast Cancer) 12/01/2015 - "Our in vitro studies showed that Ad.dcn produced high levels of viral replication and the decorin protein in the breast tumor cells. " 01/01/2013 - "Our study also shows that transduction of decorin in decorin-negative human breast cancer cells markedly modulates the growth pattern of these cells." 11/01/2015 - "Prognostic value of stromal decorin expression in patients with breast cancer: a meta-analysis." 01/01/2014 - "Periostin suppression induces decorin secretion leading to reduced breast cancer cell motility and invasion." 01/01/2013 - "We also examined the effect of decorin transduction on the behavior of cultured human breast cancer MCF7 cells. "

Related Drugs and Biologics

1.	Collagen
2.	Transforming Growth Factor beta (TGF-beta)
3.	Messenger RNA (mRNA)
4.	Phosphotransferases (Kinase)
5.	Liposomes (Liposome)
6.	Proteoglycans (Proteoglycan)
7.	Biglycan
8.	Transforming Growth Factor beta1 (TGF beta 1)
9.	Procollagen
10.	Insulin-Like Growth Factor I (IGF-1)

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Laminectomy
3.	Transplants (Transplant)
4.	Homologous Transplantation (Allograft)
5.	Therapeutics