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Sacroiliitis

Inflammation of the SACROILIAC JOINT. It is characterized by lower back pain, especially upon walking, fever, UVEITIS; PSORIASIS; and decreased range of motion. Many factors are associated with and cause sacroiliitis including infection; injury to spine, lower back, and pelvis; DEGENERATIVE ARTHRITIS; and pregnancy.
Also Known As:
Pyogenic Sacroiliitis; Septic Sacroiliitis; Pyogenic Sacroiliitides; Sacroiliitides; Sacroiliitides, Pyogenic; Sacroiliitides, Septic; Sacroiliitis, Pyogenic; Sacroiliitis, Septic; Septic Sacroiliitides
Networked: 629 relevant articles (48 outcomes, 50 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Pain (Aches)
2. Ankylosing Spondylitis
3. Arthritis (Polyarthritis)
4. Joint Diseases (Joint Disease)
5. Back Pain (Backache)

Experts

1. Sieper, Joachim: 19 articles (06/2022 - 11/2007)
2. Poddubnyy, Denis: 14 articles (06/2022 - 08/2011)
3. Rudwaleit, Martin: 13 articles (09/2022 - 11/2007)
4. van der Heijde, Désirée: 13 articles (01/2022 - 11/2011)
5. Dougados, Maxime: 12 articles (01/2021 - 11/2011)
6. Braun, J: 11 articles (08/2019 - 01/2000)
7. Maksymowych, Walter P: 8 articles (09/2022 - 06/2003)
8. Deodhar, Atul: 7 articles (09/2022 - 01/2016)
9. Haibel, Hildrun: 7 articles (06/2022 - 07/2008)
10. Landewé, Robert: 7 articles (01/2022 - 08/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Sacroiliitis:
1. Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA
2. SteroidsIBA
3. Etanercept (Enbrel)FDA Link
4. Infliximab (Remicade)FDA Link
5. HLA-B27 Antigen (HLA B27 Antigen)IBA
6. C-Reactive ProteinIBA
7. Anti-Bacterial Agents (Antibiotics)IBA
8. Adalimumab (Humira)FDA Link
9. Isotretinoin (Accutane)FDA LinkGeneric
10. Tumor Necrosis Factor InhibitorsIBA
01/01/2017 - "DWI measurements reflect the response to TNF inhibitor treatment in ERA patients with sacroiliitis as defined using radiological criteria and may also reflect clinical response. "
06/01/2016 - "MRI, together with CRP, can be helpful in selecting which patients without radiographic sacroiliitis are most likely to respond to tumor necrosis factor inhibitor therapy. "
01/01/2023 - "This study was conducted to assess the utility of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in predicting radiographic sacroiliitis and active disease in axial spondyloarthritis (SpA) and to explore the association between use of a tumor necrosis factor inhibitor (TNFi) and these laboratory values compared with traditional inflammatory markers. "
05/01/2012 - "Recently published recommendations for the treatment of juvenile arthritis consider children with sacroiliitis in a separate group and allow for more accelerated institution of a tumor necrosis factor inhibitor depending on disease activity and prognostic factors that derive primarily from studies of other forms of juvenile arthritis. "
01/01/2023 - "In multivariable Cox proportional hazard regression analysis, the presence of syndesmophytes at diagnosis (adjusted hazard ratio [HR]: 4.50, 95% confidence interval [CI]: 1.54-13.15, p = 0.006) and active sacroiliitis on magnetic resonance imaging (MRI) at diagnosis (adjusted HR: 5.88, 95% CI: 2.05-16.82, p = 0.001) were significantly associated with a higher risk of progression to radiographic axSpA, whereas longer exposure to tumor necrosis factor inhibitors (TNFis) was significantly associated with a lower risk of progression to radiographic axSpA (adjusted HR: 0.89, 95% CI: 0.80-0.98, p = 0.022). "

Therapies and Procedures

1. Therapeutics
2. Injections
3. Arthrodesis
4. Aftercare (After-Treatment)
5. Debridement