Sacroiliitis

Inflammation of the SACROILIAC JOINT. It is characterized by lower back pain, especially upon walking, fever, UVEITIS; PSORIASIS; and decreased range of motion. Many factors are associated with and cause sacroiliitis including infection; injury to spine, lower back, and pelvis; DEGENERATIVE ARTHRITIS; and pregnancy.

Also Known As:

Networked: 378 relevant articles (20 outcomes, 22 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pain (Aches)
2.	Ankylosing Spondylitis
3.	Arthritis (Polyarthritis)
4.	Spondylarthropathies
5.	Psoriasis (Pustulosis Palmaris et Plantaris)

Experts

1.	Sieper, Joachim: 10 articles (08/2015 - 11/2007)
2.	Braun, J: 10 articles (09/2014 - 01/2000)
3.	Sieper, J: 8 articles (01/2011 - 01/2000)
4.	van der Heijde, Désirée: 6 articles (08/2015 - 11/2011)
5.	van der Heijde, D: 6 articles (09/2014 - 05/2004)
6.	Dougados, Maxime: 5 articles (09/2014 - 11/2011)
7.	Rudwaleit, Martin: 5 articles (11/2011 - 11/2007)
8.	Rudwaleit, M: 5 articles (01/2011 - 05/2004)
9.	Poddubnyy, Denis: 4 articles (08/2015 - 08/2011)
10.	Braun, Jürgen: 4 articles (08/2014 - 07/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Sacroiliitis:

1.	TNFR-Fc fusion protein (etanercept)FDA Link 01/01/2014 - "Sacroiliitis on MRI improved in 9 subjects with the greatest improvement in MRI composite score ratio after initiation of etanercept therapy. " 04/01/2011 - "[Successful therapy of sacroiliitis in SAPHO syndrome by etanercept]." 02/29/2008 - "This demonstrates that etanercept therapy may be an appropriate therapeutic agent for sacroiliitis in MCTD patients, as it is in AS alone." 02/29/2008 - "In our case report, we demonstrate a good response to etanercept therapy for refractory sacroiliitis in a patient with coexisting AS and MCTD, without development of a lupus-like syndrome. " 02/29/2008 - "Successful etanercept therapy for refractory sacroiliitis in a patient with ankylosing spondylitis and mixed connective tissue disease."
2.	infliximab (Remicade)FDA Link 04/01/2009 - "To evaluate the efficacy of infliximab in HLA-B27-positive patients with magnetic resonance imaging (MRI)-determined early sacroiliitis, using both clinical and MRI assessments. " 04/01/2009 - "Clinical and imaging efficacy of infliximab in HLA-B27-Positive patients with magnetic resonance imaging-determined early sacroiliitis." 08/01/2013 - "The blood flow signals in the sacroiliac joints became weaker or even disappeared and the RI values increased in patients with active sacroiliitis after infliximab treatment. " 04/01/2009 - "Infliximab was an effective therapy for early sacroiliitis, providing a reduction in disease activity by week 16. " 03/01/2009 - "Clinical and radiographic response to a local infliximab injection in a patient with chronic sacroiliitis."
3.	HLA-B27 Antigen (HLA B27 Antigen)IBA 05/01/2013 - "HLA-B27 was negatively associated with longterm remission status, possibly because of its association with clinical disease characteristics, such as sacroiliitis, rather than being a general marker of persistent disease." 03/01/1984 - "In the population study of 2,957 individuals 45 years or older, we found 5 cases of HLA-B27 positive sacroiliitis (according to the New York criteria) and 3 of these fulfilled the New York criteria for diagnosis of AS. " 07/01/1982 - "In a study designed to clarify the relationship of HLA-B27 and sacroiliitis, 45 members of seven Old Order Amish families were thoroughly evaluated for sacroiliitis. " 04/01/2015 - "Sacroiliitis and HLA-B27 are considered to be equivalent criteria for the diagnosis of SpA. " 01/01/2015 - "Presence of sacroiliitis on magnetic-resonance-imaging (MRI) or HLA-B27 adds to diagnostic certainty. "
4.	adalimumab (Humira)FDA Link 11/01/2015 - "Our study found that CDUS could be used to detect the changes of sacroiliitis and peripheral enthesitis in AS patients under adalimumab therapy." 07/01/2008 - "Adalimumab is the first TNF antagonist to demonstrate good clinical efficacy and safety in patients with axial SpA without radiographically defined sacroiliitis." 07/01/2008 - "Efficacy of adalimumab in the treatment of axial spondylarthritis without radiographically defined sacroiliitis: results of a twelve-week randomized, double-blind, placebo-controlled trial followed by an open-label extension up to week fifty-two." 11/01/2015 - "To investigate whether colour Doppler ultrasonography (CDUS) can be used to detect the effect of adalimumab on sacroiliitis and peripheral enthesitis in patients with ankylosing spondylitis (AS). " 11/01/2015 - "Colour Doppler ultrasonography can be used to detect the changes of sacroiliitis and peripheral enthesitis in patients with ankylosing spondylitis during adalimumab treatment."
5.	Adrenal Cortex Hormones (Corticosteroids)IBA 12/01/2006 - "Oral corticosteroids helped ameliorate the sacroiliitis. " 12/01/2002 - "Sacroiliitis responds well to intra-articular corticosteroids. " 03/01/2000 - "The aim of this study was to evaluate the advantages of MRguided injections of corticosteroids into the sacroiliac joints (SIJ) in patients suffering from refractory sacroiliitis despite appropriate oral therapy. " 08/01/2010 - "IA injections of SIJs with corticosteroids are often performed in patients suffering from low back pain due to active sacroiliitis. " 11/15/2008 - "Sacroiliitis is often caused by rheumatic diseases, and besides other therapeutic options, treatment consists of intraarticular injection of corticosteroids. "
6.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 12/01/2012 - "Inflammatory back pain, sacroiliitis and good respond to NSAIDs were the most frequently used criteria (92.9 %, 36.2 % and 33.3% respectively). " 02/01/2009 - "The patient was diagnosed with AS in 1989 based on detection of cervical ankylosis and sacroiliitis on X-ray and was given NSAIDs. " 12/01/2005 - "Twenty patients with documented seronegative peripheral arthritis, ankylosing spondylitis, or sacroiliitis, who had not taken nonsteroidal anti-inflammatory drugs (NSAIDs) in the preceding 2 months, participated in the study. " 06/01/2011 - "The diagnosis of ankylosing spondylitis was retained in a 64-year-old woman suffering from inflammatory back and neck pain combined with buttock pain relieved by anti-inflammatory drugs (NSAIDs) since 2004 and more recent bilateral heel pain in the morning since 2006; sacroiliitis was grade 3 on the right and grade 2 on the left (modified New-York criteria). " 12/01/2012 - "In Belgium, 208 referral physicians assigned to 16 rheumatology centres were randomized to refer chronic back pain patients (with onset <45 years) using 1 of the 2 referral strategies: Strategy 1 :1 of 3 criteria (inflammatory back pain, HLA-B27, sacroiliitis on imaging); or Strategy 2: 2 of6 criteria (IBP inflammatory back pain, HLA-B27, sacroiliitis, family history, good response to NSAIDs, extra-articular manifestations). "
7.	MethylprednisoloneFDA LinkGeneric 01/01/1999 - "The results of our study indicate that the periarticular injection of methylprednisolone may be effective in the treatment of clinical sacroiliitis in patients with seronegative spondylarthropathy."
8.	C-Reactive ProteinIBA 03/01/2006 - "Improvement in sacroiliitis index, Schober test, occipital wall test, finger-ground distance, as well as the erythrocyte sedimentation rate (ESR) and the content of C-reactive protein (CRP) in Group B and C was far superior to that of Group A (P < 0.01). " 01/01/2015 - "In the univariate logistic regression analyses, older age, longer disease duration, severe sacroiliitis, elevated C-reactive protein (CRP) levels at baseline, and one or more pre-existing syndesmophytes were associated with the occurrence of new syndesmophytes. " 07/01/2014 - "Elevated C-reactive protein and active sacroiliitis on magnetic resonance imaging are strongest predictors of structural damage development in the sacroiliac joints and, therefore, of progression from nonradiographic to radiographic stage. " 08/01/2011 - "An elevated level of C-reactive protein (CRP) at baseline was a strong positive predictor of radiographic sacroiliitis progression in non-radiographic axial spondyloarthritis and AS (OR 3.65 and 5.08, respectively, p<0.05). " 06/01/2011 - "Elevated C-reactive protein levels and advanced sacroiliitis were also significantly associated with the presence of spinal involvement without fusion (P < 0.05). "
9.	Isotretinoin (Accutane)FDA LinkGeneric 10/01/2013 - "Bilateral acute sacroiliitis due to isotretinoin therapy: a case report." 11/01/2012 - "The cessation of isotretinoin and symptomatic treatment resolved the symptoms within 6 weeks, with no signs of sacroiliitis on repeat MRI 10 months later. " 11/01/2012 - "Sacroiliitis secondary to isotretinoin." 05/01/2010 - "We discussed possible mechanisms of sacroiliitis and disability due to isotretinoin treatment." 05/01/2010 - "Naranjo probability scale indicated a probable relationship between isotretinoin therapy and bilateral sacroiliitis. "
10.	Anti-Bacterial Agents (Antibiotics)IBA 08/01/2013 - "Although optimal antimicrobial treatment duration for infectious sacroiliitis is not well established, this case shows the early efficacy of oral antibiotics. " 06/01/2015 - "Antibiotics for empirical therapy after a diagnosis of pyogenic sacroiliitis, including anti-MRSA antibiotics, should be carefully selected." 10/01/2007 - "After a course of intravenous antibiotics, the symptoms completely resolved, thus supporting our diagnosis of bacterial sacroiliitis. " 12/01/2005 - "Eventually, a diagnosis of sacroiliitis was made and appropriate antibiotics were administered. " 10/12/2000 - "In patients with infectious sacroiliitis, antibiotics are the treatment of choice. "

Therapies and Procedures

1.	Injections 03/01/2008 - "Patients with SI joint dysfunction, as well as sacroiliitis, often get relief from image-guided SI joint therapeutic injections." 06/01/2003 - "Our initial experience suggests that sonographically guided therapeutic injections to sacroiliac joints could be valuable alternatives to other guidance modalities in patients with sacroiliitis. " 06/01/2003 - "To investigate the feasibility and effectiveness of sonographic guidance for therapeutic intra-articular sacroiliac joint injections in patients with sacroiliitis. " 02/01/2000 - "To evaluate magnetic resonance imaging (MRI) guided corticosteroid injections of inflamed sacroiliac (SI) joints in patients with spondyloarthropathy with therapy resistant sacroiliitis. " 03/01/2000 - "The aim of this study was to evaluate the advantages of MRguided injections of corticosteroids into the sacroiliac joints (SIJ) in patients suffering from refractory sacroiliitis despite appropriate oral therapy. "
2.	Aftercare (After-Treatment) 01/01/2012 - "Although after treatment all the symptoms were completely resolved, 20 months later changes suggesting active sacroiliitis on MR images were continuing." 09/01/1999 - "Color and duplex Doppler sonography were able to reveal these changes and can be used in the diagnosis of active sacroiliitis and follow-up after treatment. " 09/01/1999 - "In addition, the RI values were significantly different before and after treatment in the patients with active sacroiliitis (p < .001). " 09/01/1999 - "When an artery was detected, the resistive index (RI) was measured using duplex Doppler sonography in all groups and also after treatment in the patients with active sacroiliitis. " 10/01/2014 - "AS was associated with autoantibody targeting of PPM1A, and levels of anti-PPM1A autoantibodies were significantly higher in patients with more advanced sacroiliitis and correlated positively with BASDAI score after treatment with anti-TNF agents. "
3.	Arthrodesis 01/01/2013 - "Patients with degenerative sacroiliitis or sacroiliac joint disruption resistant to nonsurgical treatments may undergo open surgery with sacroiliac joint arthrodesis, although outcomes are mixed and risks are significant. " 10/15/2001 - "After a careful selection of patients, including positive blocks in the sacroiliac joint, arthrodesis of sacroiliac joint might be considered for so-called "intractable" aseptic sacroiliitis." 10/15/2001 - "Two cases of successful sacroiliac joint arthrodesis for medically intractable aseptic sacroiliitis are reported. " 01/01/1993 - "[Results of surgical therapy of bacterial sacroiliitis with primary arthrodesis]." 10/15/2001 - "Although successful arthrodesis of the sacroiliac joint had been reported previously for septic sacroiliitis, no report had shown the procedure to be effective for spondylarthropathy. "
4.	Drug Therapy (Chemotherapy) 12/01/2006 - "Induction chemotherapy failed to induce a complete remission of AML, but it did effectively treat the sacroiliitis. " 01/01/1995 - "We describe a case of purulent sacroiliitis due to Haemophilus paraphrophilus where the organism was initially misidentified as Eikenella corrodens leading to inappropriate antimicrobial chemotherapy. "
5.	Vegetarian Diet (Vegetarianism) 08/01/2001 - "[Clinical remission of an HLA B27-positive sacroiliitis on vegan diet]." 08/01/2001 - "It was demonstrated that in a single case of sacroiliitis which was refractory to other treatment, vegan diet resulted in a convincingly improvement of complaints."