Phosphatidylinositol-4-Phosphate 3-Kinase

A phosphatidylinositol 3-kinase that catalyzes the conversion of 1-phosphatidylinositol 4-phosphate into phosphatidylinositol 3,4-bisphosphate.

Also Known As:

1-Phosphatidylinositol-4-Phosphate 3-Kinase; 1 Phosphatidylinositol 4 Phosphate 3 Kinase; 3-Kinase, 1-Phosphatidylinositol-4-Phosphate; Phosphatidylinositol 4 Phosphate 3 Kinase

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Lu, Shun: 1 article (01/2018)
2.	Pan, Xiaoqing: 1 article (01/2018)
3.	Wang, Guan: 1 article (01/2018)
4.	Wen, Danyi: 1 article (01/2018)
5.	Xu, Yunhua: 1 article (01/2018)
6.	Zhang, Feifei: 1 article (01/2018)
7.	Zhang, Jie: 1 article (01/2018)
8.	Zhu, Lei: 1 article (01/2018)

Related Diseases

Sarcoma (Soft Tissue Sarcoma)

01/01/2018 - "After continuous crizotinib or osimertinib treatment, WES data suggested that acquired ALK E1210K mutation conferred crizotinib resistance in the CTC15035EML4-ALK xenograft, while decreased frequencies of EGFR L858R and T790M mutations plus the appearance of v-RAF murine sarcoma viral oncogene homolog B (BRAF) G7V mutations and phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha (PIK3C2A) A86fs frame shift mutations led to osimertinib resistance in the CTC15063EGFR L858R, T790M xenografts. "

Related Drugs and Biologics

1.	Crizotinib
2.	osimertinib