Purinergic P2Y2 Receptors

A subclass of purinergic P2Y receptors that have a preference for ATP and UTP. The activated P2Y2 receptor acts through a G-PROTEIN-coupled PHOSPHATIDYLINOSITOL and intracellular CALCIUM SIGNALING pathway.

Also Known As:

Receptors, Purinergic P2Y2; P2U Receptors; P2Y2 Purinoceptor; P2Y2 Receptors; Puringergic Receptor P2Y, G-Protein Coupled, 2; Purinoreceptor P2U; P2Y2 Receptors, Purinergic; Purinoceptor, P2Y2; Receptor, P2U; Receptor, P2Y2; Receptors, P2U; Receptors, P2Y2; P2U Receptor; P2Y2 Receptor

Networked: 165 relevant articles (5 outcomes, 18 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Weisman, Gary A: 10 articles (04/2021 - 11/2002)
2.	Erb, Laurie: 7 articles (06/2020 - 11/2002)
3.	Burnstock, Geoffrey: 7 articles (01/2018 - 01/2002)
4.	Seye, Cheikh I: 6 articles (01/2017 - 11/2002)
5.	González, Fernando A: 6 articles (05/2005 - 11/2002)
6.	Müller, Christa E: 5 articles (01/2022 - 01/2006)
7.	Communi, Didier: 4 articles (01/2022 - 09/2010)
8.	Kim, Hye Jung: 4 articles (07/2020 - 04/2014)
9.	Kishore, Bellamkonda K: 4 articles (01/2020 - 10/2005)
10.	Zhang, Yue: 4 articles (01/2020 - 01/2012)

Related Diseases

1.	Dry Eye Syndromes (Dry Eye Syndrome) 01/01/2014 - "P2Y2 receptor agonists for the treatment of dry eye disease: a review." 01/01/2004 - "The relevance of P2Y2 receptor technology to dry eye disease and the disease process is discussed." 01/01/2020 - "Diquafosol is a P2Y2 receptor agonist that has been shown to be effective in the treatment of dry eye disease (DED) in short-term studies; however, its long-term safety and effectiveness have not been evaluated in a real-world setting. " 01/01/2023 - "The clinical benefits of diquafosol tetrasodium (DQS), a hydrophilic P2Y2 receptor agonist for dry eye, have been hindered by a demanding dosing regimen. " 11/01/2019 - "Age-Related Conjunctival P2Y2 Receptor Alterations in the Cu, Zn-Superoxide Dismutase-1 (Sod1)-Knockout Dry Eye Model Mice."
2.	Astrocytoma (Pilocytic Astrocytoma) 02/01/2000 - "The present studies investigated the phenomenon of P2Y2 receptor desensitization in human 1321N1 astrocytoma cells expressing recombinant wild type and C-terminal truncation mutants of the P2Y2 receptor. " 10/18/2019 - "In 1321N1 astrocytoma cells Cav-1 interacts with the P2Y2 receptor (P2Y2R) to modulate its downstream signaling. " 10/01/2004 - "In this investigation, we used human 1321N1 astrocytoma cells expressing a recombinant P2Y2 receptor to assess the role of this receptor in the regulation of anti-apoptotic (bcl-2 and bcl-xl) and pro-apoptotic (bax) gene expression. " 10/18/2019 - "Caveolin-1 Regulates P2Y2 Receptor Signaling during Mechanical Injury in Human 1321N1 Astrocytoma." 06/03/2016 - "Caveolin-1 Regulates the P2Y2 Receptor Signaling in Human 1321N1 Astrocytoma Cells."
3.	Alzheimer Disease (Alzheimer's Disease) 01/01/2020 - "Exercise training ameliorates cerebrovascular dysfunction in a murine model of Alzheimer's disease: role of the P2Y2 receptor and endoplasmic reticulum stress." 01/01/2020 - "Collectively, our results demonstrate for the first time that exercise mitigates cerebrovascular dysfunction in AD through modulating P2Y2 receptor- and ER stress-dependent endothelial dysfunction.NEW & NOTEWORTHY A limited study has investigated whether exercise training can improve cerebrovascular function in Alzheimer's disease. " 01/01/2020 - "These data suggest that exercise training, which regulates P2Y2 receptor and ER stress in AD brain, is a potential therapeutic strategy for Alzheimer's disease." 01/01/2016 - "There is evidence for a role for P2Y2 receptors in Alzheimer's disease pathology. "
4.	Polyuria 01/01/2018 - "Genetic Deletion of P2Y2 Receptor Offers Long-Term (5 Months) Protection Against Lithium-Induced Polyuria, Natriuresis, Kaliuresis, and Collecting Duct Remodeling and Cell Proliferation." 01/01/2018 - "Previously, using a 2-week lithium-induced NDI model, we reported that P2Y2 receptor (R) knockout mice are significantly resistant to polyuria, natriuresis, kaliuresis, and decrease in AQP2 protein abundance in the kidney relative to wild type mice. " 01/01/2012 - "Genetic deletion of the P2Y2 receptor offers significant resistance to development of lithium-induced polyuria accompanied by alterations in PGE2 signaling." 06/01/2015 - "Taking a cue from this phenomenon, we discovered the potential involvement of ATP/UTP-activated P2Y2 receptor in lithium-induced NDI in rats and showed that P2Y2 receptor knockout mice are significantly resistant to Li-induced polyuria, natriuresis and kaliuresis. "
5.	Neoplasms (Cancer) 09/01/2012 - "These data define the expression profile of P2Y receptors on human biliary epithelial cancer cells and indicate P2Y2 receptors as being potential targets in new treatment strategies for biliary cancer." 09/01/2012 - "This confirms the functional expression of purinoceptor P2Y2 and P2Y4 in biliary epithelial cancer cell membranes. " 01/01/1996 - "The deduced amino acid sequence of the mammary tumor cell P2U receptor was 98% homologous with that of mouse NG108-15 cells. " 01/01/1996 - "Expression cloning and signal transduction pathway of P2U receptor in mammary tumor cells." 08/12/2023 - "Tumoral P2Y2 receptor modulates tumor growth and host anti-tumor immune responses in a syngeneic murine model of oral cancer."

Related Drugs and Biologics

1.	diquafosol
2.	Calcium
3.	Mucins
4.	Lithium
5.	AR-C118925
6.	Adenosine Triphosphate (ATP)
7.	Uridine Triphosphate (UTP)
8.	GTP-Binding Proteins (G-Protein)
9.	Gq-G11 GTP-Binding Protein alpha Subunits (Gq Protein)
10.	Complementary DNA (cDNA)

Related Therapies and Procedures

1.	Therapeutics
2.	Punctures
3.	Nephrectomy
4.	Ligation
5.	Fluid Therapy (Oral Rehydration Therapy)