Ionotropic Glutamate Receptors

A class of ligand-gated ion channel receptors that have specificity for GLUTAMATE. They are distinct from METABOTROPIC GLUTAMATE RECEPTORS which act through a G-protein-coupled mechanism.

Also Known As:

Networked: 173 relevant articles (0 outcomes, 23 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Meador-Woodruff, James H: 5 articles (08/2013 - 02/2004)
2.	Mutolo, Donatella: 5 articles (05/2013 - 09/2007)
3.	Pantaleo, Tito: 5 articles (05/2013 - 09/2007)
4.	Bongianni, Fulvia: 5 articles (05/2013 - 09/2007)
5.	Cinelli, Elenia: 4 articles (05/2013 - 07/2008)
6.	Rogawski, Michael A: 4 articles (03/2011 - 01/2007)
7.	Molnár, Elek: 3 articles (05/2015 - 09/2008)
8.	Haroutunian, Vahram: 3 articles (08/2013 - 02/2004)
9.	Jayaraman, Vasanthi: 2 articles (08/2015 - 07/2014)
10.	MacLean, David M: 2 articles (08/2015 - 07/2014)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 12/28/2000 - "A disturbance in glutamatergic transmission has been suggested to contribute to the pathophysiology of schizophrenia and recent studies on ionotropic glutamate receptors are consistent with altered glutamatergic function in the hippocampus of schizophrenics. " 06/01/2012 - "Recent advances in targeting the ionotropic glutamate receptors in treating schizophrenia." 09/15/2009 - "Ionotropic glutamate receptors mediate the majority of vertebrate excitatory synaptic transmission and are therapeutic targets for cognitive enhancement and treatment of schizophrenia. " 11/01/2002 - "These results suggest that ionotropic glutamate receptors are differentially altered in the anterior cingulate region in schizophrenia. " 11/01/2002 - "Selective alterations in ionotropic glutamate receptors in the anterior cingulate cortex in schizophrenia."
2.	Seizures (Seizure) 09/01/1997 - "Earlier studies of some other authors showed an increase in NPY expression in the hippocampus during seizures and activation of ionotropic glutamate receptors. " 05/01/2015 - "Effects of repetitive seizures on ionotropic glutamate receptors (iGluRs) were investigated in rat entorhinal cortex slices. " 09/01/2009 - "These changes in ionotropic glutamate receptors are consistent with reduced excitability at glutamatergic synapses following repeated 4-AP induced seizures." 01/01/2009 - "Clinical signs of ASP include seizures and neuronal damage from activation of ionotropic glutamate receptors. " 05/01/2007 - "It is clear that enhanced glutamatergic excitatory synaptic transmission with alterations in the expression of ionotropic glutamate receptors is a mechanism critical for seizure susceptibility and excitotoxicity. "
3.	Anoxia (Hypoxia) 03/01/2002 - "The purpose of this study was: (i) to determine whether ionotropic glutamate receptors and L-type Ca(2+) channels are involved in the development of epileptiform activity induced by repeated exposures of hippocampal slices to hypoxia; and (ii) to compare the properties of hypoxia- and high K(+)(o)-induced hyperexcitability. " 04/18/2007 - "Levin, Neuronal hyperexcitability induced by repeated brief episodes of hypoxia in rat hippocampal slices: involvement of ionotropic glutamate receptors and L-type Ca2+ channels, Neuropharmacology 42 (2002) 459-466]. " 03/22/2005 - "Levin, Neuronal hyperexcitability induced by repeated brief episodes of hypoxia in rat hippocampal slices: involvement of ionotropic glutamate receptors and L-type Ca2+ channels, Neuropharmacology 42 (2002) 459-466, S.V. Kalemenev, A.V. Savin, S.G. " 03/01/2002 - "Neuronal hyperexcitability induced by repeated brief episodes of hypoxia in rat hippocampal slices: involvement of ionotropic glutamate receptors and L-type Ca(2+) channels." 08/11/2006 - "Many neurons subjected to hypoxia in the presence of blockers of ionotropic glutamate receptors developed the electron microscopic features of necrosis. "
4.	Brain Ischemia (Cerebral Ischemia) 12/01/2010 - "Effects of blockade of ionotropic glutamate receptors on blood-brain barrier disruption in focal cerebral ischemia." 02/01/2003 - "Ionotropic glutamate receptors: still a target for neuroprotection in brain ischemia? " 04/01/2001 - "Alterations in the expression of ionotropic glutamate receptors (GluR) contribute to neuronal loss after brain ischemia and epilepsy. " 01/01/2005 - "Organotypic hippocampal slice cultures represent a feasible model for studies of cerebral ischemia and the role of ionotropic glutamate receptors in oxygen-glucose deprivation-induced neurodegeneration. " 12/01/2010 - "Our data demonstrated that blockade of NMDA or AMPA receptors could attenuate the BBB disruption in focal cerebral ischemia and suggest that ionotropic glutamate receptors are involved in part in BBB disruption."
5.	Pain (Aches) 06/01/2011 - "Here, the authors review recent findings on the roles of ionotropic glutamate receptors in synaptic plasticity in the dorsal horn in relation to acute and persistent pain." 06/01/2011 - "Synaptic plasticity and pain: role of ionotropic glutamate receptors." 12/01/2009 - "This review will cover recent findings on pre- and postsynaptic regulation of synaptic function by ionotropic glutamate receptors in the dorsal horn and how such mechanisms contribute to acute and chronic pain." 09/24/2008 - "Ionotropic glutamate receptors play important roles in spinal processing of nociceptive sensory signals and induction of central sensitization in chronic pain. " 01/01/2005 - "The purpose of the present review is to correlate recent knowledge of the role of peripheral ionotropic glutamate receptors in the temporomandibular joint and muscle pain from animal and human experimental pain models with findings in patients. "

Related Drugs and Biologics

1.	N-Methylaspartate (NMDA)
2.	Glutamic Acid (Glutamate)
3.	Kainic Acid (Kainate)
4.	N-Methyl-D-Aspartate Receptors (NMDA Receptors)
5.	Glutamate Receptors (Glutamate Receptor)
6.	alpha- Amino- 3- hydroxy- 5- methyl- 4- isoxazolepropionic Acid (AMPA)
7.	Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)
8.	Dopamine (Intropin)
9.	Proteins (Proteins, Gene)
10.	Glucose (Dextrose)

Related Therapies and Procedures

1.	Spinal Injections
2.	Drug Therapy (Chemotherapy)